Gene
cux2b
- ID
- ZDB-GENE-081104-176
- Name
- cut-like homeobox 2b
- Symbol
- cux2b Nomenclature History
- Previous Names
-
- cux2
- si:ch211-218i18.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be active in nucleus. Is expressed in eye; hindbrain; and telencephalon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 67. Orthologous to human CUX2 (cut like homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Takano et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cux2b | Charlton-Perkins et al., 2019 | |
| CRISPR2-cux2b | Charlton-Perkins et al., 2019 | |
| MO1-cux2b | N/A | Sinner et al., 2014 |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 67 | Alliance | Developmental and epileptic encephalopathy 67 | 618141 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CUT domain | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B1R7 | InterPro | 1456 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-109E11 | ZFIN Curated Data | |
| Contained in | BAC | CH73-192M15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-166A6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-218I18 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009303733 (1) | |||
| Genomic | GenBank:CR376829 (1) | 197983 nt | ||
| Polypeptide | UniProtKB:A0A8M3B1R7 (1) | 1456 aa |
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Feng, S., Wang, S., Wang, Y., Yang, Q., Wang, D., Li, H. (2018) Identification and expression of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in zebrafish Danio rerio: Implication for age-related biomarkers. Gene expression patterns : GEP. 29:47-58
- Jacob, A.E., Turner, C.E., Amack, J.D. (2016) Evolution and Expression of Paxillin Genes in Teleost Fish. PLoS One. 11:e0165266
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sinner, M.F., Tucker, N.R., Lunetta, K.L., Ozaki, K., Smith, J.G., Trompet, S., Bis, J.C., Lin, H., Chung, M.K., Nielsen, J.B., Lubitz, S.A., Krijthe, B.P., Magnani, J.W., Ye, J., Gollob, M.H., Tsunoda, T., Müller-Nurasyid, M., Lichtner, P., Peters, A., Dolmatova, E., Kubo, M., Smith, J.D., Psaty, B.M., Smith, N.L., Jukema, J.W., Chasman, D.I., Albert, C.M., Ebana, Y., Furukawa, T., MacFarlane, P., Harris, T.B., Darbar, D., Dörr, M., Holst, A.G., Svendsen, J.H., Hofman, A., Uitterlinden, A., Gudnason, V., Isobe, M., Malik, R., Dichgans, M., Rosand, J., Van Wagoner, D.R., METASTROKE Consortium, AFGen Consortium, Benjamin, E.J., Milan, D.J., Melander, O., Heckbert, S., Ford, I., Liu, Y., Barnard, J., Olesen, M.S., Stricker, B.H., Tanaka, T., Kääb, S., Ellinor, P.T. (2014) Integrating Genetic, Transcriptional, and Functional Analyses to Identify Five Novel Genes for Atrial Fibrillation. Circulation. 130(15):1225-35
- Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y. (2011) Function of strawberry notch Family Genes in the Zebrafish Brain Development. The Kobe journal of medical sciences. 56(5):E220-E230
1 - 7 of 7
Show