Gene
cdkn2c
- ID
- ZDB-GENE-081104-145
- Name
- cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
- Symbol
- cdkn2c Nomenclature History
- Previous Names
-
- si:ch211-165l2.2
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Is expressed in digestive system. Orthologous to human CDKN2C (cyclin dependent kinase inhibitor 2C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor | Ankyrin repeat-containing domain superfamily |
---|---|---|---|---|---|
UniProtKB:B0UXZ0 | InterPro | 170 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cdkn2c-201
(1)
|
Ensembl | 1,783 nt | ||
mRNA |
cdkn2c-202
(1)
|
Ensembl | 4,413 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
TgBAC2(cdkn2c:EGFP) |
|
| 1 | Xu et al., 2013 | |
TgBAC(cdkn2c:EGFP) |
|
| 1 | Xu et al., 2013 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-165L2 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001199994 (1) | |||
Genomic | GenBank:CR388216 (1) | 134478 nt | ||
Polypeptide | UniProtKB:B0UXZ0 (1) | 170 aa |
- Holowiecki, A., Linstrum, K., Ravisankar, P., Chetal, K., Salomonis, N., Waxman, J.S. (2020) Pbx4 limits heart size and fosters arch artery formation through partitioning second heart field progenitors and restricting proliferation. Development (Cambridge, England). 147(5):
- Jung, I.H., Jung, D.E., Chung, Y.Y., Kim, K.S., Park, S.W. (2019) Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple Organs by Regulating Cell Cycle Progression. Neoplasia (New York, N.Y.). 21:1003-1014
- Novoa, B., Pereiro, P., López-Muñoz, A., Varela, M., Forn-Cuní, G., Anchelin, M., Dios, S., Romero, A., Martinez-López, A., Medina-Gali, R.M., Collado, M., Coll, J., Estepa, A., Cayuela, M.L., Mulero, V., Figueras, A. (2019) Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress. Aging Cell. 18(5):e13020
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Iglesias, A.I., Springelkamp, H., Linde, H.V., Severijnen, L.A., Amin, N., Oostra, B., Kockx, C.E., van den Hout, M.C., van Ijcken, W.F., Hofman, A., Uitterlinden, A.G., Verdijk, R.M., Klaver, C.C., Willemsen, R., and van Duijn, C.M. (2014) Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. Human molecular genetics. 23(5):1320-32
- Xu, S., Xia, W., Zohar, Y., and Gui, J.F. (2013) Zebrafish dmrta2 Regulates the Expression of cdkn2c in Spermatogenesis in the Adult Testis. Biology of reproduction. 88(1):14
- Le, M.T., Shyh-Chang, N., Khaw, S.L., Chin, L., Teh, C., Tay, J., O'Day, E., Korzh, V., Yang, H., Lal, A., Lieberman, J., Lodish, H.F., and Lim, B. (2011) Conserved Regulation of p53 Network Dosage by MicroRNA-125b Occurs through Evolving miRNA-Target Gene Pairs. PLoS Genetics. 7(9):e1002242
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