Gene
adrb1
- ID
- ZDB-GENE-081022-145
- Name
- adrenoceptor beta 1
- Symbol
- adrb1 Nomenclature History
- Previous Names
-
- zgc:194728
- zgc:194731
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable beta1-adrenergic receptor activity. Acts upstream of or within regulation of heart rate and venous blood vessel morphogenesis. Predicted to be located in early endosome and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; eye; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ot207 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-adrb1 | (2) | |
| CRISPR2-adrb1 | (2) | |
| CRISPR3-adrb1 | (2) | |
| CRISPR4-adrb1 | (2) | |
| CRISPR5-adrb1 | Li et al., 2025 | |
| MO1-adrb1 | N/A | Wang et al., 2009 |
| MO2-adrb1 | N/A | (5) |
| MO3-adrb1 | N/A | Wang et al., 2020 |
| MO4-adrb1 | N/A | Wang et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Adrenoceptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:B3DHM6 | InterPro | 390 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225B10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194728 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194731 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128689 (1) | 1221 nt | ||
| Genomic | GenBank:CR932360 (1) | 164973 nt | ||
| Polypeptide | UniProtKB:B3DHM6 (1) | 390 aa |
- Li, W., McCurdy, S., Lopez-Ramirez, M.A., Lee, H.S., Ginsberg, M.H. (2025) Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish. eLIFE. 13:
- Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
- Joyce, W., Pan, Y.K., Garvey, K., Saxena, V., Perry, S.F. (2022) The regulation of heart rate following genetic deletion of the ß1 adrenergic receptor in larval zebrafish. Acta physiologica (Oxford, England). 235(4):e13849
- Kong, S., Zhou, D., Fan, Q., Zhao, T., Ren, C., Nie, H. (2022) Salviae miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection Protects against Myocardial Ischemia-Reperfusion Injury and Heart Failure. Computational and Mathematical Methods in Medicine. 2022:7809485
- Pan, Y.K., Julian, T., Garvey, K., Perry, S.F. (2022) Catecholamines modulate the hypoxic ventilatory response of larval zebrafish (Danio rerio). The Journal of experimental biology. 226(1):
- Li, W., Shenkar, R., Detter, M.R., Moore, T., Benavides, C.R., Lightle, R., Girard, R., Hobson, N., Cao, Y., Li, Y., Griffin, E., Gallione, C., Zabramski, J.M., Ginsberg, M.H., Marchuk, D.A., Awad, I.A. (2020) Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism. The Journal of Clinical Investigation. 131(3)
- Wang, X., Wang, S., Meng, Z., Zhao, C. (2020) Adrb1 and Adrb2b are the major β-adrenergic receptors regulating body axis straightening in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 47(12):781-784
- Li, Y.F., Canário, A.V.M., Power, D.M., Campinho, M.A. (2019) Ioxynil and diethylstilbestrol disrupt vascular and heart development in zebrafish. Environment International. 124:511-520
- Ernens, I., Lumley, A.I., Devaux, Y. (2018) Restoration of cardiac function after anaemia-induced heart failure in zebrafish. Journal of Molecular and Cellular Cardiology. 121:223-232
- Missinato, M.A., Saydmohammed, M., Zuppo, D.A., Rao, K.S., Opie, G.W., Kühn, B., Tsang, M. (2018) Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration. Development (Cambridge, England). 145(5)
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