Gene
hif1aa
- ID
- ZDB-GENE-080917-55
- Name
- hypoxia inducible factor 1 subunit alpha a
- Symbol
- hif1aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including Notch signaling pathway; hematopoietic stem cell differentiation; and macrophage migration. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gerri et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns89 | Allele with one delins | Exon 6 | Frameshift, Premature Stop | CRISPR | |
| ihb671 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb672 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| ihb673 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa6314 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13792 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16875 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hif1aa | (10) | |
| CRISPR2-hif1aa | Zebrafish Nomenclature Committee | |
| MO1-hif1aa | N/A | (5) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | HIF-1 alpha, C-terminal transactivation domain | Hypoxia-inducible factor, alpha subunit-like | Myc-type, basic helix-loop-helix (bHLH) domain | PAC motif | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QNB9 | InterPro | 717 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
hif1aa-202
(1)
|
Ensembl | 1,294 nt | ||
| mRNA |
hif1aa-201
(1)
|
Ensembl | 2,154 nt | ||
| mRNA |
hif1aa-203
(1)
|
Ensembl | 2,204 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-174E3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001308559 (1) | 2154 nt | ||
| Genomic | GenBank:BX649520 (2) | 219709 nt | ||
| Polypeptide | UniProtKB:F1QNB9 (1) | 717 aa |
- Li, S., Li, H., Bennewitz, K., Poschet, G., Buettner, M., Hausser, I., Szendroedi, J., Nawroth, P.P., Kroll, J. (2025) Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis. Metabolism: clinical and experimental. :156149156149
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Wang, Z., Zhu, C., Sun, X., Deng, H., Liu, W., Jia, S., Bai, Y., Xiao, W., Liu, X. (2024) Spring viremia of carp virus infection induces hypoxia response in zebrafish by stabilizing hif1α. Journal of virology. :e0149124e0149124
- Diogo, P., Martins, G., Simão, M., Marreiros, A., Eufrásio, A.C., Cabrita, E., Gavaia, P.J. (2023) Type I Diabetes in Zebrafish Reduces Sperm Quality and Increases Insulin and Glucose Transporter Transcripts. International Journal of Molecular Sciences. 24(8):
- Liao, Q., Deng, H., Wang, Z., Yu, G., Zhu, C., Jia, S., Liu, W., Bai, Y., Sun, X., Chen, X., Xiao, W., Liu, X. (2023) Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance. The Journal of biological chemistry. 299(12):105420
- Liao, Q., Zhu, C., Sun, X., Wang, Z., Chen, X., Deng, H., Tang, J., Jia, S., Liu, W., Xiao, W., Liu, X. (2023) Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance. The Journal of biological chemistry. 299(8):105074
- Shanaka, K.A.S.N., Jung, S., Madushani, K.P., Kim, M.J., Lee, J. (2023) Viperin mutation is linked to immunity, immune cell dynamics, and metabolic alteration during VHSV infection in zebrafish. Frontiers in immunology. 14:13277491327749
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
- He, S.M., Sun, S., Chen, A.Q., Lv, S.J., Qiu, C.Z., Wei, M.L., Liu, W., Liu, H.R., Zhang, L., Ren, D.L. (2022) Hypoxia regulates cytokines expression and neutrophils migration by ERK signaling in zebrafish. Fish & shellfish immunology. 125:212-219
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