Gene
pax7b
- ID
- ZDB-GENE-080917-54
- Name
- paired box 7b
- Symbol
- pax7b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of xanthophore differentiation and wound healing. Located in nucleus. Is expressed in several structures, including brain; hindbrain neural rod; neural crest cell; pigment cell; and trunk. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma and congenital myopathy 19. Orthologous to human PAX7 (paired box 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Nord et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014345Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nkgsaizGFFD164AGt | Transgenic insertion | Intron 4 | Unknown | DNA | |
| oz32 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| sa15267 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16225 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| umu4 | Allele with one delins | Unknown | Frameshift, Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pax7b | Berberoglu et al., 2017 | |
| TALEN1-pax7b | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alveolar rhabdomyosarcoma | Alliance | Rhabdomyosarcoma 2, alveolar | 268220 |
| congenital myopathy 19 | Alliance | Congenital myopathy 19 | 618578 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired box protein 7, C-terminal | Paired DNA-binding domain | Paired domain | PAX family | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:C0M005 | InterPro | 510 | |||||||||
| UniProtKB:A0AB32TBV6 | InterPro | 501 | |||||||||
| UniProtKB:A0AB40E8R2 | InterPro | 506 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-10C6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001146149 (1) | 4845 nt | ||
| Genomic | GenBank:FO704751 (1) | 104494 nt | ||
| Polypeptide | UniProtKB:C0M005 (1) | 510 aa |
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Lencer, E., Prekeris, R., Artinger, K.B. (2021) Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives. eLIFE. 10:
- Nord, H., Kahsay, A., Dennhag, N., Pedrosa Domellöf, F., von Hofsten, J. (2021) Genetic compensation between Pax3 and Pax7 in zebrafish appendicular muscle formation. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(9):1423-1438
- Ratnayake, D., Nguyen, P.D., Rossello, F.J., Wimmer, V.C., Tan, J.L., Galvis, L.A., Julier, Z., Wood, A.J., Boudier, T., Isiaku, A.I., Berger, S., Oorschot, V., Sonntag, C., Rogers, K.L., Marcelle, C., Lieschke, G.J., Martino, M.M., Bakkers, J., Currie, P.D. (2021) Macrophages provide a transient muscle stem cell niche via NAMPT secretion. Nature. 591(7849):281-287
- Spreafico, M., Cafora, M., Bragato, C., Capitanio, D., Marasca, F., Bodega, B., De Palma, C., Mora, M., Gelfi, C., Marozzi, A., Pistocchi, A. (2021) Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy. Pharmacological research. 170:105750
- Tschaikner, P., Regele, D., Röck, R., Salvenmoser, W., Meyer, D., Bouvier, M., Geley, S., Stefan, E., Aanstad, P. (2021) Feedback Control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish. Development (Cambridge, England). 148(4):
- Ganassi, M., Badodi, S., Wanders, K., Zammit, P.S., Hughes, S.M. (2020) Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis. eLIFE. 9:
- Li, C., Barton, C., Henke, K., Daane, J., Treaster, S., Caetano-Lopez, J., Tanguay, R.L., Harris, M. (2020) Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. eLIFE. 9:
- Peng, L., Wang, C., Li, P., Cheng, B., Hu, Y., Cheng, Y., Zheng, Q. (2020) Evaluation of hypopigmentation in embryonic zebrafish induced by emerging disinfection byproduct, 3, 5-di-I-tyrosylalanine. Aquatic toxicology (Amsterdam, Netherlands). 225:105525
- Hamada, H., Uemoto, T., Tanaka, Y., Honda, Y., Kitajima, K., Umeda, T., Kawakami, A., Shinya, M., Kawakami, K., Tamura, K., Abe, G. (2019) Pattern of fin rays along the antero-posterior axis based on their connection to distal radials. Zoological letters. 5:30
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