Gene

cacnb2a

ID
ZDB-GENE-080808-7
Name
calcium channel, voltage-dependent, beta 2a
Symbol
cacnb2a Nomenclature History
Previous Names
  • CAB2b.1 (1)
  • CACNB2.1 (1)
  • cacnb2b (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable high voltage-gated calcium channel activity. Acts upstream of or within embryonic heart tube morphogenesis; glial cell development; and retina development in camera-type eye. Predicted to be located in sarcolemma. Predicted to be part of voltage-gated calcium channel complex. Is expressed in several structures, including gill; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
a246Allele with multiple variantsUnknownUnknownCRISPR
sa45305Allele with one point mutationUnknownMissense, Premature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-cacnb2a
    		Charlton-Perkins et al., 2019
    CRISPR2-cacnb2aThyme et al., 2019
    CRISPR3-cacnb2aThyme et al., 2019
    CRISPR4-cacnb2aThyme et al., 2019
    CRISPR5-cacnb2aThyme et al., 2019
    CRISPR10-cacnb2a
      		Charlton-Perkins et al., 2019
      MO1-cacnb2aN/AChernyavskaya et al., 2012
      MO2-cacnb2aN/AChernyavskaya et al., 2012
      1 - 8 of 8
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      Human Disease
      Associated With cacnb2a Human Ortholog
      Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
      Brugada syndrome 4 Alliance Brugada syndrome 4 611876
      1 - 1 of 1
      Associated With cacnb2a Via Experimental Models
      No data available
      Gene Ontology
      Protein Domains
      Domain, Family, and Site Summary
      Type InterPro ID Name
      Domain IPR001452 SH3 domain
      Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
      Domain IPR035605 CACNB2, SH3 domain
      Domain IPR046937 Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain
      Family IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
      1 - 5 of 8 Show all
      Domain Details Per Protein
      Protein Additional Resources Length CACNB2, SH3 domain Guanylate kinase/L-type calcium channel beta subunit P-loop containing nucleoside triphosphate hydrolase SH3 domain SH3-like domain superfamily Voltage-dependent calcium channel, L-type, beta-2 subunit Voltage-dependent calcium channel, L-type, beta subunit Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain
      UniProtKB:A2SZ54 InterPro 598
      UniProtKB:A0AB13AA17 InterPro 629
      UniProtKB:A0A8M1NCD9 InterPro 598
      UniProtKB:A0AB32TUD5 InterPro 571
      UniProtKB:A0AB32TUG0 InterPro 636
      1 - 5 of 6 Show all
      Transcripts
      Genome Browsers
      Genome Build: GRCz11Chromosome: 7
      Type Name Annotation Method Has Havana Data Length (nt) Analysis
      aberrant processed transcript cacnb2a-203 (1)
      Ensembl
      		Ensembl 1,929 nt
      ZFIN BLAST
      aberrant processed transcript cacnb2a-204 (1)
      Ensembl
      		Ensembl 2,207 nt
      ZFIN BLAST
      aberrant processed transcript cacnb2a-207 (1)
      Ensembl
      		Ensembl 2,432 nt
      ZFIN BLAST
      aberrant processed transcript cacnb2a-208 (1)
      Ensembl
      		Ensembl 2,206 nt
      ZFIN BLAST
      mRNA cacnb2a-201 (1)
      Ensembl
      		Ensembl 1,943 nt
      ZFIN BLAST
      1 - 5 of 8 Show all
      Interactions and Pathways
      No data available
      Antibodies
      No data available
      Plasmids
      No data available
      Constructs
      No data available
      Marker Relationships
      Relationship Marker Type Marker Accession Numbers Citations
      Contained inBACCH211-111G18ZFIN Curated Data
      1 - 1 of 1
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      Sequences
      Type Accession # Sequence Length (nt/aa) Analysis
      RNARefSeq:NM_001423819 (1)2190 nt
      ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
      GenomicGenBank:CU607104 (1)167602 nt
      MegaBLASTEnsembl
      PolypeptideUniProtKB:A0AB32TUG0 (1)636 aa
      ZFIN BLASTSIB BLASTEnsembl Protein Blast
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanCACNB210
      Amino acid sequence comparison (2)
      Conserved genome location (synteny) (1)
      MouseCacnb22
      Amino acid sequence comparison (2)
      Citations
      TSV
      1 - 8 of 8
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