Gene
usp13
- ID
- ZDB-GENE-080724-7
- Name
- ubiquitin specific peptidase 13
- Symbol
- usp13 Nomenclature History
- Previous Names
-
- wu:fc61g08 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and ubiquitin binding activity. Predicted to be involved in several processes, including protein K63-linked deubiquitination; protein stabilization; and regulation of autophagy. Predicted to act upstream of or within autophagy; protein deubiquitination; and proteolysis. Predicted to be active in cytosol and nucleus. Orthologous to human USP13 (ubiquitin specific peptidase 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025483Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029210Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15297 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17094 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33881 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-usp13 | N/A | Tse et al., 2009 |
| MO2-usp13 | N/A | Deo et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR001607 | Zinc finger, UBP-type |
| Domain | IPR015940 | Ubiquitin-associated domain |
| Domain | IPR041432 | Ubiquitinyl hydrolase, variant UBP zinc finger |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | UBA-like superfamily | Ubiquitin-associated domain | Ubiquitin carboxyl-terminal hydrolases | Ubiquitin specific protease, conserved site | Ubiquitinyl hydrolase | Ubiquitinyl hydrolase, variant UBP zinc finger | Zinc finger, RING/FYVE/PHD-type | Zinc finger, UBP-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q650 | InterPro | 852 | ||||||||||
| UniProtKB:A0A8M9PZR8 | InterPro | 853 | ||||||||||
| UniProtKB:A0A8M2BD89 | InterPro | 859 | ||||||||||
| UniProtKB:F1QFS9 | InterPro | 860 | ||||||||||
| UniProtKB:A0A2R8Q3R9 | InterPro | 860 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-196O12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-201H21 | ZFIN Curated Data | |
| Encodes | EST | fc61g08 | ||
| Encodes | cDNA | MGC:163140 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098386 (1) | 3546 nt | ||
| Genomic | GenBank:AL928701 (1) | 188745 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q3R9 (1) | 860 aa |
- Han, Y., Qian, J., Zhang, J., Hu, C., Wang, C. (2017) Structure-toxicity relationship of cefoperazone and its impurities to developing zebrafish by transcriptome and Raman analysis. Toxicology and applied pharmacology. 327:39-51
- Deo, R.C., Musso, G., Tasan, M., Tang, P., Poon, A., Yuan, C., Felix, J.F., Vasan, R.S., Beroukhim, R., De Marco, T., Kwok, P.Y., MacRae, C.A., Roth, F.P. (2014) Prioritizing causal disease genes using unbiased genomic features. Genome biology. 15:534
- Tseng, L.C., Zhang, C., Cheng, C.M., Xu, H., Hsu, C.H., Jiang, Y.J. (2014) New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS One. 9:e93394
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Lagman, D., Sundström, G., Daza, D.O., Abalo, X.M., and Larhammar, D. (2012) Expansion of transducin subunit gene families in early vertebrate tetraploidizations. Genomics. 100(4):203-211
- Tse, W.K., Eisenhaber, B., Ho, S.H., Ng, Q., Eisenhaber, F., and Jiang, Y.J. (2009) Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics. 10:637
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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