Gene

foxo1b

ID
ZDB-GENE-080425-3
Name
forkhead box O1 b
Symbol
foxo1b Nomenclature History
Previous Names
  • foxo1a.2 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within lymph vessel development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in head; olfactory epithelium; and pericardial region. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb466Allele with one deletionExon 2UnknownCRISPR
ihb467Allele with one deletionExon 2UnknownCRISPR
sa34936Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-foxo1bZebrafish Nomenclature Committee
MO1-foxo1bN/A (2)
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Human Disease
Associated With foxo1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alveolar rhabdomyosarcoma Alliance Rhabdomyosarcoma, alveolar 268220
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Associated With foxo1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Domain IPR032067 FOXO protein, transactivation domain
Domain IPR032068 FOXO protein, KIX-binding domain
Domain IPR047408 Forkhead box protein O1, forkhead domain
1 - 5 of 7 Show all
Domain Details Per Protein
Protein Additional Resources Length Forkhead box protein O1, forkhead domain Fork head domain Fork head domain conserved site 2 FOXO protein, KIX-binding domain FOXO protein, transactivation domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:A3RK75 InterPro 629
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 10
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA foxo1b-201 (1) Ensembl 2,022 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-244D10
EncodescDNAMGC:194494ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanFOXO113
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseFoxo13
Amino acid sequence comparison (1)
Citations
1 - 10 of 22
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