Gene
foxo1b
- ID
- ZDB-GENE-080425-3
- Name
- forkhead box O1 b
- Symbol
- foxo1b Nomenclature History
- Previous Names
-
- foxo1a.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within lymph vessel development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in head; olfactory epithelium; and pericardial region. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-foxo1b | Zebrafish Nomenclature Committee | |
| MO1-foxo1b | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alveolar rhabdomyosarcoma | Alliance | Rhabdomyosarcoma, alveolar | 268220 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein O1, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXO protein, KIX-binding domain | FOXO protein, transactivation domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A3RK75 | InterPro | 629 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxo1b-201
(1)
|
Ensembl | 2,022 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244D10 | ||
| Encodes | cDNA | MGC:194494 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082857 (1) | 1890 nt | ||
| Genomic | GenBank:AL953846 (2) | 153939 nt | ||
| Polypeptide | UniProtKB:A3RK75 (1) | 629 aa |
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Liu, K., Zhu, Y., Gao, W., Han, X., Zhang, Q., Zhao, Y., Zu, Y. (2024) Resveratrol alleviates heart failure by activating foxo3a to counteract oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 181:117716117716
- Park, G., Foster, C.A., Malone-Perez, M., Hasan, A., Macias, J.J., Frazer, J.K. (2024) Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Method. Journal of immunology (Baltimore, Md. : 1950). 213(12):1902-1914
- Ikeda, D., Fujita, S., Toda, K., Yaginuma, Y., Kan-No, N., Watabe, S. (2023) Cold-induced muscle atrophy in zebrafish: Insights from swimming activity and gene expression analysis. Biochemistry and biophysics reports. 36:101570101570
- Xu, H., Mao, X., Nie, Z., Li, Y. (2023) Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free radical biology & medicine. 203:102-113
- Dos Santos, M.M., de Macedo, G.T., Prestes, A.S., Ecker, A., Müller, T.E., Leitemperger, J., Fontana, B.D., Ardisson-Araújo, D.M.P., Rosemberg, D.B., Barbosa, N.V. (2020) Modulation of Redox and insulin signaling underlie the anti-hyperglycemic and antioxidant effects of diphenyl diselenide in zebrafish. Free radical biology & medicine. 158:20-31
- Park, G., Burroughs-Garcia, J., Foster, C.A., Hasan, A., Borga, C., Frazer, J.K. (2020) Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model. Oncotarget. 11:1292-1305
- Zhao, Y., Wang, H.L., Li, T.T., Yang, F., Tzeng, C.M. (2020) Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway. Drug design, development and therapy. 14:195-206
- Gao, L., Yuan, Z., Zhou, T., Yang, Y., Gao, D., Dunham, R., Liu, Z. (2019) FOXO genes in channel catfish and their response after bacterial infection. Developmental and comparative immunology. 97:38-44
- Du, Z., Ma, H.L., Zhang, Z.Y., Zheng, J.W., Wang, Y.A. (2018) Transgenic Expression of A Venous Malformation Related Mutation, TIE2-R849W, Significantly Induces Multiple Malformations of Zebrafish.. International journal of medical sciences. 15:385-394
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