Gene
camk1da
- ID
- ZDB-GENE-080402-7
- Name
- calcium/calmodulin-dependent protein kinase 1Da
- Symbol
- camk1da Nomenclature History
- Previous Names
-
- CaMKIδ (1)
- zgc:172284
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables calcium/calmodulin-dependent protein kinase activity and protein kinase activator activity. Involved in peptidyl-serine autophosphorylation. Acts upstream of or within cartilage development; endocrine pancreas development; and pancreas regeneration. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including eye; fin; heart; muscle; and testis. Orthologous to human CAMK1D (calcium/calmodulin dependent protein kinase ID).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6928 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16156 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20203 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31375 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-camk1da | O'Hare et al., 2016 | |
| MO1-camk1da | N/A | Senga et al., 2013 |
| MO2-camk1da | N/A | O'Hare et al., 2016 |
| MO3-camk1da | N/A | O'Hare et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
| UniProtKB:B1H1J7 | InterPro | 433 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
camk1da-201
(1)
|
Ensembl | 2,842 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-201B6 | ZFIN Curated Data | |
| Contained in | BAC | CH73-251M7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-206K18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172284 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123060 (1) | 2686 nt | ||
| Genomic | RefSeq:NW_018394549 (1) | 362143 nt | ||
| Polypeptide | UniProtKB:B1H1J7 (1) | 433 aa |
- Akizuki, K., Kinumi, T., Ono, A., Senga, Y., Osawa, J., Shigeri, Y., Ishida, A., Kameshita, I., Sueyoshi, N. (2019) Autoactivation of C-terminally truncated Ca2+/calmodulin-dependent protein kinase (CaMK) Iδ via CaMK kinase-independent autophosphorylation. Archives of biochemistry and biophysics. 668:29-38
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Cardoso, J.C., Bergqvist, C.A., Felix, R.C., Larhammar, D. (2016) Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. Journal of molecular endocrinology. 57(1):73-86
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Senga, Y., Akizuki, K., Katayama, S., Shigeri, Y., Kameshita, I., Ishida, A., Sueyoshi, N. (2016) High-performance CaMKI: A highly active and stable form of CaMKIδ produced by high-level soluble expression in Escherichia coli. Biochemical and Biophysical Research Communications. 475(3):277-82
- Senga, Y., Ishida, A., Shigeri, Y., Kameshita, I., Sueyoshi, N. (2015) The Phosphatase-Resistant Isoform of CaMKI, Ca²⁺/Calmodulin-Dependent Protein Kinase Iδ (CaMKIδ), Remains in Its "Primed" Form without Ca²⁺ Stimulation. Biochemistry. 54:3617-30
- Lagman, D., Ocampo Daza, D., Widmark, J., Abalo, X.M., Sundström, G., and Larhammar, D. (2013) The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications. BMC Evolutionary Biology. 13:238
- Senga, Y., Yoshioka, K., Kameshita, I., and Sueyoshi, N. (2013) Expression and gene knockdown of zebrafish Ca2+/calmodulin-dependent protein kinase Idelta-LL. Archives of biochemistry and biophysics. 540(1-2):41-52
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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