Gene
cadm1b
- ID
- ZDB-GENE-080327-34
- Name
- cell adhesion molecule 1b
- Symbol
- cadm1b Nomenclature History
- Previous Names
-
- sc:d0664
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in membrane. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in cleithrum; immature eye; and nervous system. Human ortholog(s) of this gene implicated in breast carcinoma and prostate cancer. Orthologous to human CADM1 (cell adhesion molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0664 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa10395 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-cadm1b | Charlton-Perkins et al., 2019 | |
CRISPR2-cadm1b | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | CD80-like, immunoglobulin C2-set | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Neurexin/syndecan/glycophorin C |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B0F6R1 | InterPro | 411 | ||||||||
UniProtKB:A0AB13A9R5 | InterPro | 402 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cadm1b-201
(1)
|
Ensembl | 2,332 nt | ||
ncRNA |
cadm1b-002
(1)
|
Ensembl | 952 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-71G12 | ||
Encodes | EST | cssl:d0664 | Thisse et al., 2008 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001423722 (1) | 8119 nt | ||
Genomic | GenBank:CR848835 (2) | 216994 nt | ||
Polypeptide | UniProtKB:B0F6R1 (1) | 411 aa |
- Wang, W., Zhang, J., Li, Z., Gu, J., Qin, J., Li, J., Zhang, X., Ru, S. (2021) Bisphenol S exposure accelerates the progression of atherosclerosis in zebrafish embryo-larvae. Journal of hazardous materials. 426:128042
- Yergert, K.M., Doll, C.A., O'Rouke, R., Hines, J.H., Appel, B. (2021) Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo. PLoS Biology. 19:e3001053
- Wang, W., Ru, S., Wang, L., Qin, J., Ru, Y., Zhang, J., Zhang, X. (2020) Bisphenol S induces ectopic angiogenesis in embryos via VEGFR2 signaling, leading to lipid deposition in blood vessels of larval zebrafish. Environmental science & technology. 54(11):6822-6831
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Hughes, A.N., Appel, B. (2019) Oligodendrocytes express synaptic proteins that modulate myelin sheath formation. Nature communications. 10:4125
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Aleksejeva, E., Houel, A., Briolat, V., Levraud, J.P., Langevin, C., Boudinot, P. (2016) Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses. Developmental and comparative immunology. 57:48-56
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Desvignes, T., Contreras, A., Postlethwait, J.H. (2014) Evolution of the miR199-214 cluster and vertebrate skeletal development. RNA Biology. 11(4):281-94
- Micale, L., Loviglio, M.N., Manzoni, M., Fusco, C., Augello, B., Migliavacca, E., Cotugno, G., Monti, E., Borsani, G., Reymond, A., and Merla, G. (2012) A Fish-Specific Transposable Element Shapes the Repertoire of p53 Target Genes in Zebrafish. PLoS One. 7(10):e46642
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