Gene
lingo1a
- ID
- ZDB-GENE-080327-16
- Name
- leucine rich repeat and Ig domain containing 1a
- Symbol
- lingo1a Nomenclature History
- Previous Names
-
- sc:d0342
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable epidermal growth factor receptor binding activity and signaling receptor activity. Acts upstream of or within axon regeneration. Predicted to be active in plasma membrane. Is expressed in basal plate midbrain region; immature eye; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0342 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal recessive intellectual developmental disorder 64 | Alliance | Intellectual developmental disorder, autosomal recessive 64 | 618103 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
lingo1a-201
(1)
|
Ensembl | 1,848 nt | ||
mRNA |
lingo1a-202
(1)
|
Ensembl | 1,860 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-107D11 | ZFIN Curated Data | |
Contained in | BAC | DKEY-7N16 | ZFIN Curated Data | |
Encodes | EST | cssl:d0342 | Thisse et al., 2008 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_009297768 (1) | 8014 nt | ||
Genomic | GenBank:BX005076 (2) | 206504 nt | ||
Polypeptide | RefSeq:XP_005174327 (1) | 615 aa |
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Ansar, M., Riazuddin, S., Sarwar, M.T., Makrythanasis, P., Paracha, S.A., Iqbal, Z., Khan, J., Assir, M.Z., Hussain, M., Razzaq, A., Polla, D.L., Taj, A.S., Holmgren, A., Batool, N., Misceo, D., Iwaszkiewicz, J., de Brouwer, A.P.M., Guipponi, M., Hanquinet, S., Zoete, V., Santoni, F.A., Frengen, E., Ahmed, J., Riazuddin, S., van Bokhoven, H., Antonarakis, S.E. (2017) Biallelic variants in LINGO1 are associated with autosomal recessive intellectual disability, microcephaly, speech and motor delay. Genetics in medicine : official journal of the American College of Medical Genetics. 20(7):778-784
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Panza, P., Sitko, A.A., Maischein, H.M., Koch, I., Flötenmeyer, M., Wright, G.J., Mandai, K., Mason, C.A., Söllner, C. (2015) The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Neural Development. 10:23
- Yin, W., and Hu, B. (2014) Knockdown of Lingo1b protein promotes myelination and oligodendrocyte differentiation in zebrafish. Experimental neurology. 241:72-83
- Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677
- Abdesselem, H., Shypitsyna, A., Solis, G.P., Bodrikov, V., and Stuermer, C.A. (2009) No Nogo66- and NgR-mediated inhibition of regenerating axons in the zebrafish optic nerve. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(49):15489-15498
- O'Brien, G.S., Martin, S.M., Söllner, C., Wright, G.J., Becker, C.G., Portera-Cailliau, C., and Sagasti, A. (2009) Developmentally Regulated Impediments to Skin Reinnervation by Injured Peripheral Sensory Axon Terminals. Current biology : CB. 19(24):2086-2090
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