Gene
nfasca
- ID
- ZDB-GENE-080229-6
- Name
- neurofascin homolog (chicken) a
- Symbol
- nfasca Nomenclature History
- Previous Names
-
- sc:d0205
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; brain development; and cell-cell adhesion. Predicted to be located in cell surface; growth cone; and membrane. Predicted to be active in axon and plasma membrane. Is expressed in nervous system; pancreatic system; and trigeminal placode. Orthologous to human NFASC (neurofascin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d205 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Vagionitis et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la017767Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la027254Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa13971 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21901 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21902 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa27780 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa27781 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa31826 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38839 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
tum112 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-nfasca | Vagionitis et al., 2022 | |
MO1-nfasca | N/A | Voas et al., 2009 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Neurodevelopmental disorder with central and peripheral motor dysfunction | 618356 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
Domain | IPR003598 | Immunoglobulin subtype 2 |
Domain | IPR003599 | Immunoglobulin domain subtype |
Domain | IPR003961 | Fibronectin type III |
Domain | IPR007110 | Immunoglobulin-like domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | Immunoglobulin subtype 2 | Neurofascin, immunoglobulin-like domain | Neurofascin/L1/NrCAM, C-terminal domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PUN4 | InterPro | 1168 | |||||||||||
UniProtKB:A0A8M9QHH2 | InterPro | 1379 | |||||||||||
UniProtKB:C0L978 | InterPro | 1369 | |||||||||||
UniProtKB:A0AB32TWN4 | InterPro | 1178 | |||||||||||
UniProtKB:A0AB32TXA3 | InterPro | 1377 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
nfasca-201
(1)
|
Ensembl | 6,288 nt | ||
mRNA |
nfasca-202
(1)
|
Ensembl | 9,923 nt | ||
mRNA |
nfasca-203
(1)
|
Ensembl | 4,007 nt | ||
mRNA |
nfasca-204
(1)
|
Ensembl | 4,110 nt | ||
mRNA |
nfasca-205
(1)
|
Ensembl | 4,066 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-158N23 | ZFIN Curated Data | |
Encodes | cDNA | cssl:d205 | Bushell et al., 2007 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001145767 (1) | 4110 nt | ||
Genomic | GenBank:CR354444 (2) | 218819 nt | ||
Polypeptide | UniProtKB:A0AB32U331 (1) | 1391 aa |
- Vagionitis, S., Auer, F., Xiao, Y., Almeida, R.G., Lyons, D.A., Czopka, T. (2022) Clusters of neuronal neurofascin prefigure the position of a subset of nodes of Ranvier along individual central nervous system axons in vivo. Cell Reports. 38:110366
- Yang, S., Emelyanov, A., You, M.S., Sin, M., Korzh, V. (2020) Camel regulates development of the brain ventricular system. Cell and tissue research. 383(2):835-852
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lambert, M.J., Olsen, K.G., Cooper, C.D. (2014) Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish. Gene. 546(2):271-6
- Lagman, D., Ocampo Daza, D., Widmark, J., Abalo, X.M., Sundström, G., and Larhammar, D. (2013) The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications. BMC Evolutionary Biology. 13:238
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Voas, M.G., Glenn, T.D., Raphael, A.R., and Talbot, W.S. (2009) Schwann Cells Inhibit Ectopic Clustering of Axonal Sodium Channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(46):14408-14414
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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