Gene
egr4
- ID
- ZDB-GENE-080204-90
- Name
- early growth response 4
- Symbol
- egr4 Nomenclature History
- Previous Names
-
- zgc:175128
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in brain. Used to study congenital heart disease. Orthologous to human EGR4 (early growth response 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-egr4 | Liu et al., 2022 | |
| MO1-egr4 | N/A | Liu et al., 2022 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB + MO1-egr4 | standard conditions | Liu et al., 2022 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:A9JTG0 | InterPro | 352 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-290K24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175128 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114453 (1) | 1980 nt | ||
| Genomic | GenBank:CU681841 (2) | 100884 nt | ||
| Polypeptide | UniProtKB:A9JTG0 (1) | 352 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | EGR4 | 2 | Amino acid sequence comparison (1) |
- He, X., Wang, Z., Cheng, L., Wang, H., Sun, Y. (2025) An antagonistic role of clock genes and lima1 in kidney regeneration. Communications biology. 8:2929
- Wang, Y., Sun, X., Xiong, B., Duan, M., Sun, Y. (2024) Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish. International Journal of Molecular Sciences. 25(17):
- Liu, S., Wei, W., Wang, P., Liu, C., Jiang, X., Li, T., Li, F., Wu, Y., Chen, S., Sun, K., Xu, R. (2022) LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. PLoS Genetics. 18:e1010530e1010530
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Wilson, P.W., Cho, C., Allsing, N., Khanum, S., Bose, P., Grubschmidt, A., Sant, K.E. (2022) Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos. Birth defects research. 115(4):458-473
- Ren, J., Long, Y., Liu, R., Song, G., Li, Q., Cui, Z. (2021) Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. International Journal of Molecular Sciences. 22(6):
- Gans, I., Hartig, E.I., Zhu, S., Tilden, A.R., Hutchins, L.N., Maki, N.J., Graber, J.H., Coffman, J.A. (2020) Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Scientific Reports. 10:11415
- Kenyon, A., Gavriouchkina, D., Zorman, J., Napolitani, G., Cerundolo, V., Sauka-Spengler, T. (2017) Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum. Scientific Reports. 7:6505
- Wu, M., Liu, S., Hu, L., Qu, H., Pan, C., Lei, P., Shen, Y., Yang, M. (2017) Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Aquatic toxicology (Amsterdam, Netherlands). 192:274-283
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