Gene
hbegfa
- ID
- ZDB-GENE-080204-119
- Name
- heparin-binding EGF-like growth factor a
- Symbol
- hbegfa Nomenclature History
- Previous Names
-
- zgc:175091
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable epidermal growth factor receptor binding activity and growth factor activity. Acts upstream of or within response to wounding; retina development in camera-type eye; and sensory epithelium regeneration. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in retina. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from El-Brolosy et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns189 | Allele with one deletion | Exon 3 | Premature Stop | CRISPR | |
| bns203 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| bns243 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| pd362 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa18135 | Allele with one point mutation | Exon 3 | Premature Stop | ENU | |
| sa31972 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42344 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| umo84 | Allele with one deletion | Unknown | Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hbegfa | (2) | |
| CRISPR2-hbegfa | El-Brolosy et al., 2019 | |
| CRISPR3-hbegfa | El-Brolosy et al., 2019 | |
| CRISPR4-hbegfa | Cigliola et al., 2023 | |
| CRISPR5-hbegfa | Cigliola et al., 2023 | |
| MO1-hbegfa | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Diphtheria, susceptibility to} |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain |
|---|---|---|---|
| UniProtKB:A9JRW9 | InterPro | 230 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hbegfa-201
(1)
|
Ensembl | 1,808 nt | ||
| ncRNA |
hbegfa-002
(1)
|
Ensembl | 760 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:hbegfa-2A-TagBFP) |
| 1 | Cigliola et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-269I13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175091 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001111226 (1) | 1770 nt | ||
| Genomic | GenBank:CU855621 (1) | 79189 nt | ||
| Polypeptide | UniProtKB:A9JRW9 (1) | 230 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Boyd, P., Campbell, L.J., Hyde, D.R. (2023) Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina. Frontiers in cell and developmental biology. 11:11425861142586
- Cigliola, V., Shoffner, A., Lee, N., Ou, J., Gonzalez, T.J., Hoque, J., Becker, C.J., Han, Y., Shen, G., Faw, T.D., Abd-El-Barr, M.M., Varghese, S., Asokan, A., Poss, K.D. (2023) Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Nature communications. 14:48574857
- Lau, E.S., Zhu, B., Sun, M.A., Ngai, S.M., Ge, W. (2023) Proteomic analysis of zebrafish Folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian Folliculogenesis. Biology of reproduction. 109(4):482-497
- Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
- Campbell, C.A., Fursova, O., Cheng, X., Snella, E., McCune, A., Li, L., Solchenberger, B., Schmid, B., Sahoo, D., Morton, M., Traver, D., Espín-Palazón, R. (2021) A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation. Blood advances. 5:796-811
- Sahu, A., Devi, S., Jui, J., Goldman, D. (2021) Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury. Glia. 69(12):2882-2898
- Biswas, S., Ghosh, S., Samanta, A., Das, S., Mukherjee, U., Maitra, S. (2020) Bisphenol A impairs reproductive fitness in zebrafish ovary: Potential involvement of oxidative/nitrosative stress, inflammatory and apoptotic mediators. Environmental pollution (Barking, Essex : 1987). 267:115692
- Flinn, M.A., Otten, C., Brandt, Z.J., Bostrom, J.R., Kenarsary, A., Wan, T.C., Auchampach, J.A., Abdelilah-Seyfried, S., O'Meara, C.C., Link, B.A. (2020) Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development (Cambridge, England). 147(16):
- Lee, M., Wan, J., Goldman, D. (2020) Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration. eLIFE. 9:
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