Gene
mst1rb
- ID
- ZDB-GENE-071218-3
- Name
- macrophage stimulating 1 receptor b
- Symbol
- mst1rb Nomenclature History
- Previous Names
-
- prgfr3
- ron2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within bone mineralization. Predicted to be located in endomembrane system and membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in corpuscles of Stannius and pronephros. Human ortholog(s) of this gene implicated in nasopharynx carcinoma. Orthologous to human MST1R (macrophage stimulating 1 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Huitema et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mst1rb | N/A | (2) |
| MO2-mst1rb | N/A | Huitema et al., 2012 |
| MO3-mst1rb | N/A | Huitema et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Nasopharyngeal carcinoma, susceptibility to, 3} | 617075 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001627 | Sema domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin repeat | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | PSI domain | Receptor Tyrosine Kinase | Sema domain | Sema domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, HGF/MSP receptor | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QI71 | InterPro | 1374 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mst1rb-201
(1)
|
Ensembl | 4,140 nt | ||
| mRNA |
mst1rb-202
(1)
|
Ensembl | 4,131 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-261I24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009306193 (1) | 7845 nt | ||
| Genomic | GenBank:BX293991 (1) | 198825 nt | ||
| Polypeptide | UniProtKB:A0A8M9QI71 (1) | 1374 aa |
- Hatzold, J., Wessendorf, H., Pogoda, H.M., Bloch, W., Hammerschmidt, M. (2021) The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development. Developmental Biology. 476:148-170
- He, Z., Crenshaw, E., Raper, J.A. (2019) Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. Biochemical and Biophysical Research Communications. 517(1):23-28
- Challa, A.K., and Chatti, K. (2013) Conservation and Early Expression of Zebrafish Tyrosine Kinases Support the Utility of Zebrafish as a Model for Tyrosine Kinase Biology. Zebrafish. 10(3):264-74
- Huitema, L.F., Renn, J., Logister, I., Gray, J.K., Waltz, S.E., Flik, G., and Schulte-Merker, S. (2012) Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(10):4092-4101
- Vanoevelen, J., Janssens, A., Huitema, L.F., Hammond, C.L., Metz, J.R., Flik, G., Voets, T., and Schulte-Merker, S. (2011) Trpv5/6 is vital for epithelial calcium uptake and bone formation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25(9):3197-207
- Carney, T.J., von der Hardt, S., Sonntag, C., Amsterdam, A., Topczewski, J., Hopkins, N., and Hammerschmidt, M. (2007) Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development (Cambridge, England). 134(19):3461-3471
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