Gene
ifngr1l
- ID
- ZDB-GENE-071120-8
- Name
- interferon gamma receptor 1-like
- Symbol
- ifngr1l Nomenclature History
- Previous Names
-
- crfb13
- ifngr1-1
- IFNGR1-1 (1)
- si:ch211-165e15.2
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and cytokine receptor activity. Predicted to be involved in cell surface receptor protein serine/threonine kinase signaling pathway; cytokine-mediated signaling pathway; and positive regulation of osteoblast differentiation. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in brain; cardiovascular system; gill; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Orthologous to human IFNGR1 (interferon gamma receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la018387Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa35395 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
immunodeficiency 27A | Alliance | Immunodeficiency 27A, mycobacteriosis, AR | 209950 |
immunodeficiency 27B | Alliance | Immunodeficiency 27B, mycobacteriosis, AD | 615978 |
{H. pylori infection, susceptibility to} | 600263 | ||
{Hepatitis B virus infection, susceptibility to} | 610424 | ||
{Tuberculosis infection, protection against} | 607948 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
Domain | IPR003961 | Fibronectin type III |
Family | IPR015615 | Transforming growth factor-beta-related |
Family | IPR050650 | Type II Cytokine and Tissue Factor Receptors |
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Domain Details Per Protein
Protein | Additional Resources | Length | Cystine-knot cytokine | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related | Type II Cytokine and Tissue Factor Receptors |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:D2JGP1 | InterPro | 385 | ||||||||
UniProtKB:D2CN89 | InterPro | 423 | ||||||||
UniProtKB:A0A8M1NVW3 | InterPro | 385 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ifngr1l-201
(1)
|
Ensembl | 1,497 nt | ||
mRNA |
ifngr1l-202
(1)
|
Ensembl | 517 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-52P7 | ZFIN Curated Data | |
Contained in | BAC | CH211-165E15 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001171589 (1) | 1497 nt | ||
Genomic | GenBank:CR450691 (1) | 157371 nt | ||
Polypeptide | UniProtKB:D2CN89 (1) | 423 aa |
- Deng, Y.H., Li, B., Chen, S.N., Ren, L., Zhang, B.D., Liu, L.H., Liu, S., Nie, P. (2023) Molecular characterization of nineteen cytokine receptor family B (CRFB) members, CRFB1, CRFB2, CRFB4-17, with three CRFB9 and two CRFB14 in a cyprinid fish, the blunt snout bream Megalobrama amblycephala. Developmental and comparative immunology. 145:104725
- Chen, S.N., Gan, Z., Hou, J., Yang, Y.C., Huang, L., Huang, B., Wang, S., Nie, P. (2022) Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Nature communications. 13:999
- Lin, C., Tang, Y., Wang, Y., Zhang, J., Li, Y., Xu, S., Xia, B., Zhai, Q., Li, Y., Zhang, L., Liu, J. (2022) WhiB4 Is Required for the Reactivation of Persistent Infection of Mycobacterium marinum in Zebrafish. Microbiology spectrum. 10(2):e0044321
- Zhang, C.N., Zhang, J.L., Huang, Y., Ren, H.T., Guan, S.H., Zeng, Q.H. (2017) Dibutyltin depressed immune functions via NF-κB, and JAK/STAT signaling pathways in zebrafish (Danio rerio). Environmental toxicology. 33(1):104-111
- Fredericksen, F., Villalba, M., Olavarría, V.H. (2016) Characterization of bovine A20 gene: Expression mediated by NF-κB pathway in MDBK cells infected with bovine viral diarrhea virus-1. Gene. 581(2):117-29
- Yang, Q., Liu, X., Zhou, T., Cook, J., Nguyen, K., Bai, X. (2016) RNA polymerase II pausing differentially regulates signaling pathway genes to control hematopoietic stem cell emergence in zebrafish. Blood. 128(13):1701-10
- Chen, H., Liu, W., Wang, B., Mao, H., Sun, Z., Hou, Q., Mi, Y., Fan, L., Hu, C. (2015) Cloning, identification of the two cytokine receptor family B subunits CRFB1 and CRFB5 from grass carp (Ctenopharyngodon idella). Fish & shellfish immunology. 45(2):211-20
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Li, Y., Esain, V., Teng, L., Xu, J., Kwan, W., Frost, I.M., Yzaguirre, A.D., Cai, X., Cortes, M., Maijenburg, M.W., Tober, J., Dzierzak, E., Orkin, S.H., Tan, K., North, T.E., Speck, N.A. (2014) Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 28(23):2597-612
- Sawamiphak, S., Kontarakis, Z., Stainier, D.Y. (2014) Interferon Gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence. Developmental Cell. 31:640-653
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