Gene
satb2
- ID
- ZDB-GENE-070912-212
- Name
- SATB homeobox 2
- Symbol
- satb2 Nomenclature History
- Previous Names
-
- si:ch211-223c6.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within epiboly involved in gastrulation with mouth forming second; neural crest cell development; and zygotic genome activation. Predicted to be located in nuclear lumen. Is expressed in fin; head; nervous system; pharyngeal endoderm; and pronephric duct. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB2 (SATB homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a325 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa7194 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11148 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31727 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| svn1 | Allele with one delins | Exon 1 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| SATB2-associated syndrome | Alliance | Glass syndrome | 612313 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CUT domain | DNA-binding protein SATB1/SATB2 | Homedomain-like superfamily | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily | SATB, CUT1-like DNA-binding domain | SATB, CUTL domain superfamily | SATB, ubiquitin-like oligomerisation domain | SATB, ULD domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8WIP9 | InterPro | 834 | |||||||||
| UniProtKB:A0A8M2BFS5 | InterPro | 981 | |||||||||
| UniProtKB:A0A8M6Z0X7 | InterPro | 980 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-165B19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-223C6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128532 (1) | 2505 nt | ||
| Genomic | GenBank:BX571724 (1) | 174709 nt | ||
| Polypeptide | UniProtKB:A0A8M2BFS5 (1) | 981 aa |
- Lozano, D., López, J.M., Jiménez, S., Morona, R., Ruíz, V., Martínez, A., Moreno, N. (2023) Expression of SATB1 and SATB2 in the brain of bony fishes: what fish reveal about evolution. Brain structure & function. 228(3-4):921-945
- Shainer, I., Kuehn, E., Laurell, E., Al Kassar, M., Mokayes, N., Sherman, S., Larsch, J., Kunst, M., Baier, H. (2023) A single-cell resolution gene expression atlas of the larval zebrafish brain. Science advances. 9:eade9909
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:
- Matrone, G., Xia, B., Chen, K., Denvir, M.A., Baker, A.H., Cooke, J.P. (2021) Fli1+ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 118(31):
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275
- Askary, A., Xu, P., Barske, L., Bay, M., Bump, P., Balczerski, B., Bonaguidi, M.A., Crump, J.G. (2017) Genome-wide analysis of facial skeletal regionalization in zebrafish. Development (Cambridge, England). 144(16):2994-3005
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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