Gene
kif5aa
- ID
- ZDB-GENE-070912-141
- Name
- kinesin family member 5A, a
- Symbol
- kif5aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within axonal transport of mitochondrion and neuron projection maintenance. Predicted to be located in cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in gonad; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 25; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151650 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ic3023 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| ic3024 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| la029551Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s1614 | unknown | Unknown | Unknown | ENU | |
| sa7168 | Allele with one point mutation | Unknown | Splice Site, Premature Stop | ENU | |
| sa10562 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27306 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kif5aa | Auer et al., 2014 | |
| CRISPR2-kif5aa | Di Donato et al., 2016 | |
| CRISPR3-kif5aa | Di Donato et al., 2016 | |
| TALEN1-kif5aa | (5) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 25 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to, 25} | 617921 |
| hereditary spastic paraplegia 10 | Alliance | Spastic paraplegia 10, autosomal dominant | 604187 |
| Myoclonus, intractable, neonatal | 617235 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q504B9 | InterPro | 349 | |||||
| UniProtKB:A0A0R4IWI7 | InterPro | 1033 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kif5aa-201
(1)
|
Ensembl | 4,604 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(kif5aa:EGFP-bsmir29,myl7:EGFP) |
|
| 1 | Ripa et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-166E11 | ZFIN Curated Data | |
| Encodes | EST | fj61a10 | ||
| Encodes | EST | IMAGE:7151650 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001199776 (1) | 4604 nt | ||
| Genomic | GenBank:CR848672 (2) | 57909 nt | ||
| Polypeptide | UniProtKB:A0A0R4IWI7 (1) | 1033 aa |
- Grimaud, B., Frétaud, M., Terras, F., Bénassy, A., Duroure, K., Bercier, V., Trippé-Allard, G., Mohammedi, R., Gacoin, T., Del Bene, F., Marquier, F., Langevin, C., Treussart, F. (2022) In Vivo Fast Nonlinear Microscopy Reveals Impairment of Fast Axonal Transport Induced by Molecular Motor Imbalances in the Brain of Zebrafish Larvae. ACS nano. 16(12):20470-20487
- Ducommun Priest, M., Navarro, M.F., Bremer, J., Granato, M. (2019) Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration. PLoS Genetics. 15:e1007982
- Nimura, T., Itoh, T., Hagio, H., Hayashi, T., Di Donato, V., Takeuchi, M., Itoh, T., Inoguchi, F., Sato, Y., Yamamoto, N., Katsuyama, Y., Del Bene, F., Shimizu, T., Hibi, M. (2019) Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish. Developmental Biology. 455(2):393-408
- Ripa, R., Dolfi, L., Terrigno, M., Pandolfini, L., Savino, A., Arcucci, V., Groth, M., Terzibasi Tozzini, E., Baumgart, M., Cellerino, A. (2017) MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging. BMC Biology. 15:9
- Di Donato, V., De Santis, F., Auer, T., Testa, N., Sánchez-Iranzo, H., Mercader, N., Concordet, J.P., Del Bene, F. (2016) 2C-Cas9: a versatile tool for clonal analysis of gene function. Genome research. 26(5):681-92
- Auer, T.O., Xiao, T., Bercier, V., Gebhardt, C., Duroure, K., Concordet, J.P., Wyart, C., Suster, M., Kawakami, K., Wittbrodt, J., Baier, H., Del Bene, F. (2015) Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. eLIFE. 4
- Auer, T.O., Duroure, K., De Cian, A., Concordet, J.P., and Del Bene, F. (2014) Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome research. 24(1):142-53
- Campbell, P.D., Shen, K., Sapio, M.R., Glenn, T.D., Talbot, W.S., Marlow, F.L. (2014) Unique Function of Kinesin Kif5A in Localization of Mitochondria in Axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:14717-32
- Campbell, P.D., and Marlow, F.L. (2013) Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development. Gene expression patterns : GEP. 13(7):271-279
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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