Gene
icn2
- ID
- ZDB-GENE-070822-9
- Name
- ictacalcin 2
- Symbol
- icn2 Nomenclature History
- Previous Names
-
- s100i2 (1)
- zgc:171263
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; heart; integument; renal system; and sensory system. Orthologous to several human genes including S100A2 (S100 calcium binding protein A2) and S100A4 (S100 calcium binding protein A4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-icn2 | Charlton-Perkins et al., 2019 | |
CRISPR2-icn2 | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | S-100 | S100/CaBP-9k-type, calcium binding, subdomain | S100/Calcium binding protein 7/8-like, conserved site |
---|---|---|---|---|---|---|---|---|
UniProtKB:A3FKT8 | InterPro | 97 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-216F21 | ZFIN Curated Data | |
Encodes | cDNA | MGC:171263 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195270 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195274 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001082957 (1) | 459 nt | ||
Genomic | GenBank:CR533578 (1) | 214872 nt | ||
Polypeptide | UniProtKB:A3FKT8 (1) | 97 aa |
No data available
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Zhang, C., Zhang, Q., Wang, J., Tian, J., Song, Y., Xie, H., Chang, M., Nie, P., Gao, Q., Zou, J. (2019) Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Fish & shellfish immunology. 94:685-696
- Lissouba, A., Liao, M., Kabashi, E., Drapeau, P. (2018) Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines. Frontiers in molecular neuroscience. 11:463
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kraemer, A.M., Saraiva, L.R., and Korsching, S.I. (2008) Structural and functional diversification in the teleost S100 family of calcium-binding proteins. BMC Evolutionary Biology. 8:48
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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