Gene

lig4

ID
ZDB-GENE-070820-10
Name
ligase IV, DNA, ATP-dependent
Symbol
lig4 Nomenclature History
Previous Names
  • zgc:165595 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Acts upstream of or within double-strand break repair via nonhomologous end joining. Predicted to be located in nucleus. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; multiple myeloma; pancreatic cancer; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
fh302Allele with one point mutationUnknownUnknownENU
fh303Allele with one point mutationUnknownUnknownENU
lig4_unrecoveredAllele with one point mutationUnknownUnknownENU
mhn7Allele with one deletionUnknownUnknownCRISPR
sa13669Allele with one point mutationUnknownPremature StopENU
sa32694Allele with one point mutationUnknownPremature StopENU
sa38268Allele with one point mutationUnknownPremature StopENU
zko558aAllele with one deletionUnknownUnknownCRISPR
zko558bAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With lig4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
DNA ligase IV deficiency Alliance LIG4 syndrome 606593
multiple myeloma Alliance {Multiple myeloma, resistance to} 254500
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Associated With lig4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016059 DNA ligase, ATP-dependent, conserved site
Domain IPR001357 BRCT domain
Domain IPR012308 DNA ligase, ATP-dependent, N-terminal
Domain IPR012309 DNA ligase, ATP-dependent, C-terminal
Domain IPR012310 DNA ligase, ATP-dependent, central
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Domain Details Per Protein
Protein Additional Resources Length BRCT domain BRCT domain superfamily DNA ligase 4 DNA Ligase 4, adenylation domain DNA ligase, ATP-dependent DNA ligase, ATP-dependent, central DNA ligase, ATP-dependent, conserved site DNA ligase, ATP-dependent, C-terminal DNA ligase, ATP-dependent, N-terminal DNA ligase, ATP-dependent, N-terminal domain superfamily DNA ligase IV domain Nucleic acid-binding, OB-fold
UniProtKB:A7E283 InterPro 909
UniProtKB:F1Q9E8 InterPro 909
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA lig4-201 (1) Ensembl 3,262 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-198K9ZFIN Curated Data
EncodescDNAMGC:165595ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanLIG413
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseLig48
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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