Gene
lig4
- ID
- ZDB-GENE-070820-10
- Name
- ligase IV, DNA, ATP-dependent
- Symbol
- lig4 Nomenclature History
- Previous Names
-
- zgc:165595 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Acts upstream of or within double-strand break repair via nonhomologous end joining. Predicted to be located in nucleus. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; multiple myeloma; pancreatic cancer; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| DNA ligase IV deficiency | Alliance | LIG4 syndrome | 606593 |
| multiple myeloma | Alliance | {Multiple myeloma, resistance to} | 254500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016059 | DNA ligase, ATP-dependent, conserved site |
| Domain | IPR001357 | BRCT domain |
| Domain | IPR012308 | DNA ligase, ATP-dependent, N-terminal |
| Domain | IPR012309 | DNA ligase, ATP-dependent, C-terminal |
| Domain | IPR012310 | DNA ligase, ATP-dependent, central |
| Domain | IPR021536 | DNA ligase IV domain |
| Domain | IPR044125 | DNA Ligase 4, adenylation domain |
| Family | IPR000977 | DNA ligase, ATP-dependent |
| Family | IPR029710 | DNA ligase 4 |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR036420 | BRCT domain superfamily |
| Homologous_superfamily | IPR036599 | DNA ligase, ATP-dependent, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | DNA ligase 4 | DNA Ligase 4, adenylation domain | DNA ligase, ATP-dependent | DNA ligase, ATP-dependent, central | DNA ligase, ATP-dependent, conserved site | DNA ligase, ATP-dependent, C-terminal | DNA ligase, ATP-dependent, N-terminal | DNA ligase, ATP-dependent, N-terminal domain superfamily | DNA ligase IV domain | Nucleic acid-binding, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A7E283 | InterPro | 909 | ||||||||||||
| UniProtKB:F1Q9E8 | InterPro | 909 |
Interactions and Pathways
No data available
Plasmids
No data available