Gene
clcn2a
- ID
- ZDB-GENE-070705-19
- Name
- chloride channel, voltage-sensitive 2a
- Symbol
- clcn2a Nomenclature History
- Previous Names
-
- clc-2a (1)
- clcn2
- si:ch211-117k11.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Located in cell junction. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2).
- Genome Resources
- Note
-
In communications with Alejandro Barrallo Gimeno, it was determined that this gene will be renamed clcn2a in his pending publication.
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary hyperaldosteronism | Alliance | Hyperaldosteronism, familial, type II | 605635 |
| Leukoencephalopathy with ataxia | 615651 | ||
| {Epilepsy, idiopathic generalized, susceptibility to, 11} | 607628 | ||
| {Epilepsy, juvenile absence, susceptibility to, 2} | 607628 | ||
| {Epilepsy, juvenile myoclonic, susceptibility to, 8} | 607628 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CBS domain superfamily | Chloride channel | Chloride channel ClC-2 | Chloride channel, core | Voltage-gated chloride channel |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QJE6 | InterPro | 477 | |||||
| UniProtKB:F1Q5F4 | InterPro | 979 | |||||
| UniProtKB:A0A8M9QJE0 | InterPro | 940 | |||||
| UniProtKB:A0AB32TSQ3 | InterPro | 962 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
clcn2a-201
(1)
|
Ensembl | 3,380 nt | ||
| mRNA |
clcn2a-203
(1)
|
Ensembl | 1,970 nt | ||
| ncRNA |
clcn2a-002
(1)
|
Ensembl | 800 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-377B14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-117K11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328709 (1) | |||
| Genomic | GenBank:BX296556 (1) | 181230 nt | ||
| Polypeptide | UniProtKB:F1Q5F4 (1) | 979 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Pérez-Rius, C., Castellanos, A., Gaitán-Peñas, H., Navarro, A., Artuch, R., Barrallo-Gimeno, A., Estévez, R. (2019) Role of zebrafish ClC-K/barttin channels in apical kidney chloride reabsorption. The Journal of physiology. 597(15):3969-3983
- Shu, T., Shu, Y., Gao, Y., Jin, X., He, J., Zhai, G., Yin, Z. (2018) Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL. Frontiers in endocrinology. 9:683
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Pérez-Rius, C., Gaitán-Peñas, H., Estévez, R., Barrallo-Gimeno, A. (2015) Identification and characterization of the zebrafish ClC-2 chloride channel orthologs. Pflugers Archiv : European journal of physiology. 467(8):1769-81
- Wang, Y.F., Yan, J.J., Tseng, Y.C., Chen, R.D., Hwang, P.P. (2015) Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. International journal of biological sciences. 11:1190-203
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