Gene
kif5bb
- ID
- ZDB-GENE-070629-4
- Name
- kinesin family member 5B, b
- Symbol
- kif5bb Nomenclature History
- Previous Names
-
- wu:fi31h03
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within bone morphogenesis; cartilage development; and skeletal muscle tissue development. Predicted to be located in cytoplasm and microtubule. Is expressed in several structures, including digestive system; eye; pleuroperitoneal region; spinal cord neural tube; and trigeminal placode. Orthologous to human KIF5B (kinesin family member 5B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ae21 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| ae22 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| ae23 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| ae24 | Allele with one insertion | Unknown | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kif5bb | Santos-Ledo et al., 2017 | |
| MO1-kif5bb | N/A | Tao et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IRM1 | InterPro | 959 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kif5bb-201
(1)
|
Ensembl | 3,227 nt | ||
| mRNA |
kif5bb-202
(1)
|
Ensembl | 3,122 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002664019 (1) | 3728 nt | ||
| Genomic | GenBank:FP236323 (1) | 99948 nt | ||
| Polypeptide | UniProtKB:A0A0R4IRM1 (1) | 959 aa |
- Xie, B., Liang, J., Jiang, J., Zeng, T., Liu, L., Xie, D., Zhu, G., Xiong, L., Zhang, K., Liu, D., Gong, J., Chen, X., Lai, R., Xie, H. (2024) Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling. Frontiers in molecular neuroscience. 17:14051091405109
- Tao, B., Hu, H., Chen, J., Chen, L., Luo, D., Sun, Y., Ge, F., Zhu, Z., Trudeau, V.L., Hu, W. (2022) Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification. EMBO reports. 23(6):e54387
- Samarut, É., Swaminathan, A., Riché, R., Liao, M., Hassan-Abdi, R., Renault, S., Allard, M., Dufour, L., Cossette, P., Soussi-Yanicostas, N., Drapeau, P. (2018) γ-Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment. Epilepsia. 59(11):2061-2074
- Santos-Ledo, A., Garcia-Macia, M., Campbell, P.D., Gronska, M., Marlow, F.L. (2017) Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis. PLoS Genetics. 13:e1006918
- Campbell, P.D., Shen, K., Sapio, M.R., Glenn, T.D., Talbot, W.S., Marlow, F.L. (2014) Unique Function of Kinesin Kif5A in Localization of Mitochondria in Axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:14717-32
- Campbell, P.D., and Marlow, F.L. (2013) Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development. Gene expression patterns : GEP. 13(7):271-279
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