Gene
sap130a
- ID
- ZDB-GENE-070615-5
- Name
- Sin3A-associated protein a
- Symbol
- sap130a Nomenclature History
- Previous Names
-
- zgc:162722
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable glucan 1,4-alpha-glucosidase activity. Acts upstream of or within several processes, including floor plate formation; larval locomotory behavior; and thigmotaxis. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. Used to study hypoplastic left heart syndrome. Orthologous to human SAP130 (Sin3A associated protein 130).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hypoplastic left heart syndrome | AB + MO2-sap130a | standard conditions | Liu et al., 2017 |
| hypoplastic left heart syndrome | sap130apt32a/pt32a | standard conditions | Liu et al., 2017 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone deacetylase complex subunit SAP130 | Histone deacetylase complex subunit SAP130, C-terminal domain |
|---|---|---|---|---|
| UniProtKB:A0A8M6YZH6 | InterPro | 1039 | ||
| UniProtKB:A0A8M3ATE0 | InterPro | 1055 | ||
| UniProtKB:F1REK0 | InterPro | 1072 | ||
| UniProtKB:A0A8M2BD75 | InterPro | 1071 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sap130a-201
(1)
|
Ensembl | 4,417 nt | ||
| mRNA |
sap130a-202
(1)
|
Ensembl | 934 nt |
Interactions and Pathways
No data available
Plasmids
No data available