Gene
gpr183a
- ID
- ZDB-GENE-070615-28
- Name
- G protein-coupled receptor 183a
- Symbol
- gpr183a Nomenclature History
- Previous Names
-
- gpr183
- ebi2
- zgc:165579
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and oxysterol binding activity. Acts upstream of or within definitive hemopoiesis; endothelial to hematopoietic transition; and negative regulation of Notch signaling pathway. Predicted to be located in plasma membrane. Is expressed in endothelial cell and ventral wall of dorsal aorta. Orthologous to human GPR183 (G protein-coupled receptor 183).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Zhang et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ioz9 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-gpr183a | Zhang et al., 2015 | |
CRISPR2-gpr183a | Kuil et al., 2019 | |
MO1-gpr183a | N/A | Zhang et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor 183-like | G protein-coupled receptor, rhodopsin-like |
---|---|---|---|---|---|
UniProtKB:A5PLE7 | InterPro | 368 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
gpr183a-201
(1)
|
Ensembl | 1,448 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-184M13 | ZFIN Curated Data | |
Encodes | cDNA | MGC:165579 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001099241 (1) | 1466 nt | ||
Genomic | GenBank:BX470183 (1) | 136116 nt | ||
Polypeptide | UniProtKB:A5PLE7 (1) | 368 aa |
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Kwon, H.B., Mackie, D.I., Bonnavion, R., Mercier, A.L., Helker, C.S.M., Son, T., Guenter, S., Serafin, D.S., Kim, K.W., Offermanns, S., Caron, K.M., Stainier, D.Y.R. (2020) The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling. ACS pharmacology & translational science. 3:676-689
- Kuil, L.E., Oosterhof, N., Geurts, S.N., van der Linde, H.C., Meijering, E., van Ham, T.J. (2019) Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain. Disease models & mechanisms. 12(3):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., Liu, F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Research. 25:1093-107
- Gomez, G., Lee, J.H., Veldman, M.B., Lu, J., Xiao, X., and Lin, S. (2012) Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS One. 7(3):e31658
- Chen, J., Huang, C., Zheng, L., Simonich, M., Bai, C., Tanguay, R., and Dong, Q. (2011) Trimethyltin chloride (TMT) neurobehavioral toxicity in embryonic zebrafish. Neurotoxicology and teratology. 33(6):721-6
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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