Gene
plxna3
- ID
- ZDB-GENE-070613-1
- Name
- plexin A3
- Symbol
- plxna3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Acts upstream of or within several processes, including axonogenesis; branching morphogenesis of a nerve; and embryonic skeletal joint morphogenesis. Located in membrane. Is expressed in fin; nervous system; otic vesicle; and post-vent region. Orthologous to human PLXNA3 (plexin A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016252Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la016463Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la016464Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026705Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026706Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026708Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026709Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029523Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029524Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| p13umal | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-plxna3 | van der Klaauw et al., 2019 | |
| CRISPR2-plxna3 | van der Klaauw et al., 2019 | |
| MO1-plxna3 | N/A | (5) |
| MO2-plxna3 | N/A | Feldner et al., 2007 |
| MO3-plxna3 | N/A | (2) |
| MO4-plxna3 | N/A | Yoo et al., 2016 |
| MO5-plxna3 | N/A | Yoo et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin, cytoplasmic RasGAP domain | Plexin, cytoplasmic RhoGTPase-binding domain | Plexin family | Plexin repeat | Plexin, TIG domain 1 | Plexin, TIG domain 2 | PSI domain | Rho GTPase activation protein | Sema domain | Sema domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S5N4 | InterPro | 1892 | ||||||||||||||
| UniProtKB:A0A8M3AUY1 | InterPro | 705 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
plxna3-201
(1)
|
Ensembl | 6,597 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-7I23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-14I10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-229J6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195307 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098489 (1) | 6210 nt | ||
| Genomic | GenBank:BX284664 (2) | 228202 nt | ||
| Polypeptide | UniProtKB:B0S5N4 (1) | 1892 aa |
- Halabi, R., Cechmanek, P.B., Hehr, C.L., McFarlane, S. (2022) Semaphorin3f as a cardiomyocyte derived regulator of heart chamber development. Cell communication and signaling : CCS. 20:126
- Fontenas, L., Kucenas, S. (2021) Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia. eLIFE. 10:
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- van der Klaauw, A.A., Croizier, S., Mendes de Oliveira, E., Stadler, L.K.J., Park, S., Kong, Y., Banton, M.C., Tandon, P., Hendricks, A.E., Keogh, J.M., Riley, S.E., Papadia, S., Henning, E., Bounds, R., Bochukova, E.G., Mistry, V., O'Rahilly, S., Simerly, R.B., INTERVAL, UK10K Consortium, Minchin, J.E.N., Barroso, I., Jones, E.Y., Bouret, S.G., Farooqi, I.S. (2019) Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 176(4):729-742.e18
- Moreno, R.L., Williams, K., Jones, K.L., Ribera, A.B. (2018) Investigation of Islet2a function in zebrafish embryos: Mutants and morphants differ in morphologic phenotypes and gene expression. PLoS One. 13:e0199233
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Emerson, S.E., Light, S.E., Ebert, A.M. (2017) Neuronal expression patterns of the PlexinA family during zebrafish development. Gene expression patterns : GEP. 27:56-66
- Joris, M., Schloesser, M., Baurain, D., Hanikenne, M., Muller, M., Motte, P. (2017) Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Nucleic acids research. 45:9547-9557
- Barton, R., Khakbaz, P., Bera, I., Klauda, J.B., Iovine, M.K., Berger, B.W. (2016) Interplay of specific trans- and juxtamembrane interfaces in Plexin A3 dimerization and signal transduction. Biochemistry. 55(35):4928-38
- Cardoso, J.C., Bergqvist, C.A., Felix, R.C., Larhammar, D. (2016) Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. Journal of molecular endocrinology. 57(1):73-86
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