Gene
casp3b
- ID
- ZDB-GENE-070607-1
- Name
- caspase 3, apoptosis-related cysteine peptidase b
- Symbol
- casp3b Nomenclature History
- Previous Names
-
- casp3l
- caspase-3b (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables protein homodimerization activity. Predicted to be involved in several processes, including erythrocyte differentiation; keratinocyte differentiation; and positive regulation of neuron apoptotic process. Predicted to be part of death-inducing signaling complex. Predicted to be active in cytoplasm. Is expressed in female organism; intestine; muscle cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-casp3b | Zhang et al., 2021 | |
| CRISPR2-casp3b | Zhang et al., 2021 | |
| CRISPR3-casp3b | Zhang et al., 2021 | |
| CRISPR4-casp3b | Zhang et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
| Domain | IPR011600 | Peptidase C14, caspase domain |
| Domain | IPR015917 | Peptidase C14A, caspase catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Caspase-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14 family | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QGI7 | InterPro | 224 | |||||||
| UniProtKB:A0A8M2BKT2 | InterPro | 285 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
casp3b-201
(1)
|
Ensembl | 5,614 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-225I24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001048066 (1) | 1165 nt | ||
| Genomic | GenBank:BX088718 (1) | 172246 nt | ||
| Polypeptide | UniProtKB:A0A8M2BKT2 (1) | 285 aa |
- Gawel, K., Hulas-Stasiak, M., Marszalek-Grabska, M., Grenda, A., Siekierska, A., Kosheva, N., van der Ent, W., Esguerra, C.V., Krawczyk, P., Turski, W.A. (2024) Induction of seizures and initiation of epileptogenesis by pilocarpine in zebrafish larvae. Frontiers in molecular neuroscience. 17:14186061418606
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Koslow, M., Zhu, P., McCabe, C., Xu, X., Lin, X. (2023) Kidney transcriptome and cystic kidney disease genes in zebrafish. Frontiers in Physiology. 14:11840251184025
- Liang, F., Lu, X., Wu, B., Yang, Y., Qin, W. (2023) Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling. Biology. 12(4):
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Yao, L., Clark, A.C. (2022) Comparing the folding landscapes of evolutionarily divergent procaspase-3. Bioscience Reports. 42(6)
- Cao, L., Yan, D., Xiao, J., Feng, H., Chang, M.X. (2021) The Zebrafish Antiapoptotic Protein BIRC2 Promotes Edwardsiella piscicida Infection by Inhibiting Caspases and Accumulating p53 in a p53 Transcription-Dependent and -Independent Manner. Frontiers in immunology. 12:781680
- Falfushynska, H., Horyn, O., Osypenko, I., Rzymski, P., Wejnerowski, Ł., Dziuba, M.K., Sokolova, I.M. (2021) Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. Water research. 194:116923
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