Gene
fadd
- ID
- ZDB-GENE-070606-3
- Name
- Fas (tnfrsf6)-associated via death domain
- Symbol
- fadd Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable caspase binding activity and death receptor binding activity. Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be part of CD95 death-inducing signaling complex. Is expressed in several structures, including axis; brain; germ ring; immature eye; and ventral mandibular arch. Human ortholog(s) of this gene implicated in immunodeficiency 90 and leukemia. Orthologous to human FADD (Fas associated via death domain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Serbanovic-Canic et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 90 | Alliance | Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction | 613759 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Death domain | Death effector domain | Death-like domain superfamily | FAS-associated death domain protein |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IXF0 | InterPro | 192 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
- Yi, R., Yang, B., Zhu, H., Sun, Y., Wu, H., Wang, Z., Lu, Y., He, Y.W., Tian, J. (2024) Quorum-Sensing Signal DSF Inhibits the Proliferation of Intestinal Pathogenic Bacteria and Alleviates Inflammatory Response to Suppress DSS-Induced Colitis in Zebrafish. Nutrients. 16(11):
- Zhang, X.H., Zhou, C.C., Li, C.Y., Hua, Y., Li, K., Wei, P., He, M.F. (2021) Isoliquiritin exert protective effect on telencephalon infarction injury by regulating multi-pathways in zebrafish model of ischemic stroke. Phytomedicine : international journal of phytotherapy and phytopharmacology. 83:153469
- Yang, X., Li, X., Gu, Q., Li, Q., Cui, Z. (2019) Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish. Cells. 8(9):
- Serbanovic-Canic, J., de Luca, A., Warboys, C., Ferreira, P.F., Luong, L.A., Hsiao, S., Gauci, I., Mahmoud, M., Feng, S., Souilhol, C., Bowden, N., Ashton, J.P., Walczak, H., Firmin, D., Krams, R., Mason, J.C., Haskard, D.O., Sherwin, S., Ridger, V., Chico, T.J., Evans, P.C. (2017) Zebrafish Model for Functional Screening of Flow-Responsive Genes. Arteriosclerosis, Thrombosis, and Vascular Biology. 37(1):130-143
- Hu, P., Liu, M., Liu, Y., Wang, J., Zhang, D., Niu, H., Jiang, S., Wang, J., Zhang, D., Han, B., Xu, Q., Chen, L. (2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952
- Zhou, Z.J., Sun, L. (2016) Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Frontiers in cellular and infection microbiology. 6:76
- Niu, X., Hong, J., Zheng, X., Melville, D.B., Knapik, E.W., Meng, A., Peng, J. (2014) The Nuclear Pore Complex Function of Sec13 Protein Is Required for Cell Survival during Retinal Development. The Journal of biological chemistry. 289:11971-85
- Zhao, X., Zhao, L., Tian, T., Zhang, Y., Tong, J., Zheng, X., and Meng, A. (2010) Interruption of cenph causes mitotic failure and embryonic death and its haploinsufficiency suppresses cancer in zebrafish. The Journal of biological chemistry. 285(36):27924-27934
- Sidi, S., Sanda, T., Kennedy, R.D., Hagen, A.T., Jette, C.A., Hoffmans, R., Pascual, J., Imamura, S., Kishi, S., Amatruda, J.F., Kanki, J.P., Green, D.R., D'Andrea, A.A., and Look, A.T. (2008) Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3. Cell. 133(5):864-877
- Gregory-Evans, C.Y., Moosajee, M., Hodges, M.D., Mackay, D.S., Game, L., Vargesson, N., Bloch-Zupan, A., Rüschendorf, F., Santos-Pinto, L., Wackens, G., and Gregory-Evans, K. (2007) SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma. Human molecular genetics. 16(20):2482-2493
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