Gene
tnfsf10l3
- ID
- ZDB-GENE-070606-1
- Name
- tumor necrosis factor (ligand) superfamily, member 10 like 3
- Symbol
- tnfsf10l3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in anterior lateral line neuromast; posterior lateral line neuromast; and posterior lateral line primordium.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Tumour necrosis factor domain | Tumour necrosis factor ligand 10/11 | Tumour necrosis factor-like domain superfamily |
---|---|---|---|---|---|
UniProtKB:Q0PKX9 | InterPro | 289 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
tnfsf10l3-201
(1)
|
Ensembl | 980 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-22F5 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194182 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194197 | ZFIN Curated Data |
1 - 3 of 3
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001042713 (1) | 870 nt | ||
Genomic | GenBank:BX511168 (2) | 245435 nt | ||
Polypeptide | UniProtKB:Q0PKX9 (1) | 289 aa |
No data available
- Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):
- Megerson, E., Kuehn, M., Leifer, B., Bell, J.M., Snyder, J.L., McGraw, H.F. (2023) Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line. iScience. 27:108678108678
- Wu, Y., Xia, Y., Li, P., Qu, H.Q., Liu, Y., Yang, Y., Lin, J., Zheng, M., Tian, L., Wu, Z., Huang, S., Qin, X., Zhou, X., Chen, S., Liu, Y., Wang, Y., Li, X., Zeng, H., Hakonarson, H., Zhuang, J. (2020) Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome. Orphanet journal of rare diseases. 15:101
- Thomas, E.D., Raible, D.W. (2019) Distinct progenitor populations mediate regeneration in the zebrafish lateral line. eLIFE. 8:
- Wang, Q., Liu, S., Hu, D., Wang, Z., Wang, L., Wu, T., Wu, Z., Mohan, C., Peng, A. (2016) Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model. Life sciences. 157:116-24
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yi, Y., Qi, H., Yuan, J., Wang, R., Weng, S., He, J., Dong, C. (2015) Functional characterization of viral tumor necrosis factor receptors encoded by cyprinid herpesvirus 3 (CyHV3) genome. Fish & shellfish immunology. 45(2):757-70
- Wiens, G.D., and Glenney, G.W. (2011) Origin and evolution of TNF and TNF receptor superfamilies. Developmental and comparative immunology. 35(12):1324-35
- Eimon, P.M., Kratz, E., Varfolomeev, E., Hymowitz, S.G., Stern, H., Zha, J., and Ashkenazi, A. (2006) Delineation of the cell-extrinsic apoptosis pathway in the zebrafish. Cell death and differentiation. 13(10):1619-1630
1 - 10 of 11
Show