Gene
dachd
- ID
- ZDB-GENE-070427-2
- Name
- dachshund d
- Symbol
- dachd Nomenclature History
- Previous Names
-
- si:ch211-176j8.3
- zgc:158869
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within glomerular filtration. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; nervous system; neural tube; otic vesicle; and pronephros. Orthologous to human DACH1 (dachshund family transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb907 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029577Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029578Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7192 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9313 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15020 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44705 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dachd | Charlton-Perkins et al., 2019 | |
| CRISPR2-dachd | Charlton-Perkins et al., 2019 | |
| MO1-dachd | N/A | Endlich et al., 2018 |
| MO2-dachd | N/A | Endlich et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dachshund domain-containing protein | Putative DNA-binding domain superfamily | Ski-like, DNA-binding domain superfamily | SKI/SNO/DAC domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BF65 | InterPro | 610 | ||||
| UniProtKB:A1L2G2 | InterPro | 611 | ||||
| UniProtKB:A0A8M2BF69 | InterPro | 610 | ||||
| UniProtKB:A0AB32TZX8 | InterPro | 567 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-211O14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-130N3 | ZFIN Curated Data | |
| Contained in | BAC | CH211-176J8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-184M13 | ZFIN Curated Data | |
| Encodes | EST | cb907 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:158869 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080673 (1) | 2431 nt | ||
| Genomic | GenBank:CU463282 | 137978 nt | ||
| Polypeptide | UniProtKB:A1L2G2 (1) | 611 aa |
No data available
- Ahmed, I., Ziab, M., Da'as, S., Hasan, W., Jeya, S.P., Aliyev, E., Nisar, S., Bhat, A.A., Fakhro, K.A., Alshabeeb Akil, A.S. (2023) Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease. Computational and structural biotechnology journal. 21:716730716-730
- Yang, L., Webb, S.E., Jin, N., Lee, H.M., Chan, T.F., Xu, G., Chan, J.C.N., Miller, A.L., Ma, R.C.W. (2021) Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. Journal of diabetes investigation. 12(5):710-727
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Endlich, N., Kliewe, F., Kindt, F., Schmidt, K., Kotb, A.M., Artelt, N., Lindenmeyer, M.T., Cohen, C.D., Döring, F., Kuss, A.W., Amann, K., Moeller, M.J., Kabgani, N., Blumenthal, A., Endlich, K. (2018) The transcription factor Dach1 is essential for podocyte function. Journal of Cellular and Molecular Medicine. 22(5):2656-2669
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Kalousova, A., Mavropoulos, A., Adams, B.A., Nekrep, N., Li, Z., Krauss, S., Stainier, D.Y., and German, M.S. (2010) Dachshund homologues play a conserved role in islet cell development. Developmental Biology. 348(2):143-152
- Hollway, G.E., Bryson-Richardson, R.J., Berger, S., Cole, N.J., Hall, T.E., and Currie, P.D. (2007) Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo. Developmental Cell. 12(2):207-219
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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