Gene
foxq1a
- ID
- ZDB-GENE-070424-74
- Name
- forkhead box Q1a
- Symbol
- foxq1a Nomenclature History
- Previous Names
-
- foxq1l
- zgc:162905
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within response to xenobiotic stimulus. Predicted to be located in nucleus. Is expressed in gut; head; inter-frontal joint; and mesenchymal cell. Orthologous to human FOXQ1 (forkhead box Q1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
bcz11 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | CRISPR | |
sa9415 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18716 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32819 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-foxq1a | (2) | |
CRISPR2-foxq1a | (2) | |
CRISPR3-foxq1a | (2) |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018122 | Fork head domain conserved site1 |
Conserved_site | IPR030456 | Fork head domain conserved site 2 |
Domain | IPR001766 | Fork head domain |
Domain | IPR047518 | Forkhead box protein Q1, forkhead domain |
Family | IPR050211 | Forkhead box domain-containing protein |
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Domain Details Per Protein
Protein | Additional Resources | Length | Forkhead box domain-containing protein | Forkhead box protein Q1, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IJS9 | InterPro | 312 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
foxq1a-201
(1)
|
Ensembl | 1,378 nt | ||
mRNA |
foxq1a-202
(1)
|
Ensembl | 1,390 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-460D17 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001243344 (1) | 1399 nt | ||
Genomic | GenBank:CU856140 (1) | 35054 nt | ||
Polypeptide | UniProtKB:A0A0R4IJS9 (1) | 312 aa |
- Rude, C.I., Tidwell, L.G., Tilton, S.C., Waters, K.M., Anderson, K.A., Tanguay, R.L. (2023) Coupling Environmental Whole Mixture Toxicity Screening with Unbiased RNA-Seq Reveals Site-Specific Biological Responses in Zebrafish. Toxics. 11(3):
- Ferre-Fernández, J.J., Muheisen, S., Thompson, S., Semina, E.V. (2022) CRISPR-Cas9-mediated functional dissection of the foxc1 genomic region in zebrafish identifies critical conserved cis-regulatory elements. Human genomics. 16:49
- Chrystal, P.W., French, C.R., Jean, F., Havrylov, S., van Baarle, S., Peturson, A.M., Xu, P., Crump, J.G., Pilgrim, D.B., Lehmann, O.J., Waskiewicz, A.J. (2021) The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning. Genes. 12(2):
- Ogawa, Y., Shiraki, T., Fukada, Y., Kojima, D. (2021) Foxq2 determines blue cone identity in zebrafish. Science advances. 7:eabi9784
- Ren, J., Long, Y., Liu, R., Song, G., Li, Q., Cui, Z. (2021) Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. International Journal of Molecular Sciences. 22(6):
- Tarashansky, A.J., Musser, J.M., Khariton, M., Li, P., Arendt, D., Quake, S.R., Wang, B. (2021) Mapping single-cell atlases throughout Metazoa unravels cell type evolution. eLIFE. 10:
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Earley, A.M., Dixon, C.T., Shiau, C.E. (2018) Genetic analysis of zebrafish homologs of human FOXQ1, foxq1a and foxq1b, in innate immune cell development and bacterial host response. PLoS One. 13:e0194207
- Topczewska, J.M., Shoela, R.A., Tomaszewski, J.P., Mirmira, R.B., Gosain, A.K. (2016) The Morphogenesis of Cranial Sutures in Zebrafish. PLoS One. 11:e0165775
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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