Gene
nlrp3
- ID
- ZDB-GENE-070424-110
- Name
- NLR family pyrin domain containing 3
- Symbol
- nlrp3 Nomenclature History
- Previous Names
-
- si:ch211-114l13.10
- si:dkey-156m2.3
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity. Involved in NLRP3 inflammasome complex assembly and regulation of programmed cell death. Acts upstream of or within positive regulation of pyroptotic inflammatory response. Part of NLRP3 inflammasome complex. Is expressed in gill and intestine. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa31246 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32798 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32799 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32801 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nlrp3 | Tyrkalska et al., 2022 | |
| CRISPR2-nlrp3 | Sun et al., 2019 | |
| CRISPR3-nlrp3 | Sun et al., 2019 | |
| MO1-nlrp3 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 34 | Alliance | Deafness, autosomal dominant 34, with or without inflammation | 617772 |
| CINCA Syndrome | Alliance | CINCA syndrome | 607115 |
| familial cold autoinflammatory syndrome 1 | Alliance | Familial cold inflammatory syndrome 1 | 120100 |
| Muckle-Wells syndrome | Alliance | Muckle-Wells syndrome | 191900 |
| Keratoendothelitis fugax hereditaria | 148200 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | Butyrophylin-like, SPRY domain | Concanavalin A-like lectin/glucanase domain superfamily | DAPIN domain | Death-like domain superfamily | Leucine-rich repeat | Leucine-rich repeat domain superfamily | NACHT-associated domain | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | NACHT nucleoside triphosphatase | NOD1/2, winged helix domain | NOD-like receptor | P-loop containing nucleoside triphosphate hydrolase | SPRY-associated | SPRY domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YY09 | InterPro | 1121 | ||||||||||||||||
| UniProtKB:A0AB32TTK4 | InterPro | 1114 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-156m2.3-201
(1)
|
Ensembl | 6,595 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-114L13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-156M2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068222147 (1) | 6710 nt | ||
| Genomic | GenBank:CU302202 (1) | 202236 nt | ||
| Polypeptide | UniProtKB:A0A8M6YY09 (1) | 1121 aa |
- Della Vecchia, S., Imbrici, P., Liantonio, A., Naef, V., Damiani, D., Licitra, R., Bernardi, S., Marchese, M., Santorelli, F.M. (2025) Dapagliflozin ameliorates Lafora disease phenotype in a zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 183:117800117800
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Tokumaru, T., Apolinario, M.E.C., Shimizu, N., Umeda, R., Honda, K., Shikano, K., Teranishi, H., Hikida, T., Hanada, T., Ohta, K., Li, Y., Murakami, K., Hanada, R. (2024) Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease. Scientific Reports. 14:78137813
- Tyrkalska, S.D., Pedoto, A., Martínez-López, A., Ros-Lucas, J.A., Mesa-Del-Castillo, P., Candel, S., Mulero, V. (2022) Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish. Developmental and comparative immunology. 138:104523
- Shan, C., Li, M., Liu, Z., Xu, R., Qiao, F., Du, Z.Y., Zhang, M.L. (2021) Pediococcus pentosaceus Enhances Host Resistance Against Pathogen by Increasing IL-1β Production: Understanding Probiotic Effectiveness and Administration Duration. Frontiers in immunology. 12:766401
- Frame, J.M., Kubaczka, C., Long, T.L., Esain, V., Soto, R.A., Hachimi, M., Jing, R., Shwartz, A., Goessling, W., Daley, G.Q., North, T.E. (2020) Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell. 55(2):133-149.e6
- Li, J.Y., Wang, Y.Y., Shao, T., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. The Journal of biological chemistry. 295(4):1120-1141
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Hu, Y.W., Yu, Z.L., Xue, N.N., Nie, P., Chang, M.X. (2014) Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Developmental and comparative immunology. 46(2):323-32
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