Gene
ddit3
- ID
- ZDB-GENE-070410-90
- Name
- DNA-damage-inducible transcript 3
- Symbol
- ddit3 Nomenclature History
- Previous Names
-
- CHOP (1)
- zgc:162630
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; regulation of lipid biosynthetic process; and response to hypoxia. Predicted to be located in nucleus. Predicted to be part of CHOP-ATF3 complex; CHOP-ATF4 complex; and CHOP-C/EBP complex. Predicted to be active in cytoplasm. Is expressed in several structures, including caudal fin; digestive system; female organism; head; and male organism. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 71 figures from 59 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Her et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20839 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ddit3 | N/A | (2) |
| MO2-ddit3 | N/A | Her et al., 2013 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic-leucine zipper domain | DNA damage-inducible transcript 3 |
|---|---|---|---|---|
| UniProtKB:F1Q964 | InterPro | 242 | ||
| UniProtKB:A3KNX2 | InterPro | 205 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-125M22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162630 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082825 (1) | 1415 nt | ||
| Genomic | GenBank:BX950854 (2) | 171896 nt | ||
| Polypeptide | UniProtKB:F1Q964 (1) | 242 aa |
- Katoch, S., Chhimwal, J., Singh, D., Kumar, D., Patial, V. (2025) Picrosides-rich fraction from Picrorhiza kurroa attenuates steatohepatitis in zebrafish and mice by modulating lipid metabolism and inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 137:156368156368
- Zhou, X., Cao, J., Xie, J., Tong, W., Jia, B., Fu, J. (2025) Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish. Investigative ophthalmology & visual science. 66:3838
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- Légaré, V.P., Harji, Z.A., Rampal, C.J., Antonicka, H., Gurberg, T.J.N., Persia, O., Rodríguez, E.C., Shoubridge, E.A., Armstrong, G.A.B. (2024) CHCHD10P80L knock-in zebrafish display a mild ALS-like phenotype. Experimental neurology. 382:114945
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Matheny-Rabun, C., Mokashi, S.S., Radenkovic, S., Wiggins, K., Dukes-Rimsky, L., Angel, P., Ghesquiere, B., Kozicz, T., Steet, R., Morava, E., Flanagan-Steet, H. (2024) O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder. Cell Reports. 43:114976114976
- Méjécase, C., Nair, N., Sarkar, H., Soro-Barrio, P., Toms, M., Halliday, S., Linkens, K., Jaroszynska, N., Maurer, C., Owen, N., Moosajee, M. (2024) Oxidative Stress, Inflammation and Altered Glucose Metabolism Contribute to the Retinal Phenotype in the Choroideremia Zebrafish. Antioxidants (Basel, Switzerland). 13(12):
- Raas, Q., Wood, A., Stevenson, T.J., Swartwood, S., Liu, S., Kannan, R.M., Kannan, S., Bonkowsky, J.L. (2024) Generation and characterization of a zebrafish gain-of-function ACOX1 Mitchell disease model. Frontiers in pediatrics. 12:13268861326886
1 - 10 of 138
Show