Gene

ide

ID
ZDB-GENE-070410-85
Name
insulin-degrading enzyme
Symbol
ide Nomenclature History
Previous Names
  • zgc:162603 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable metalloendopeptidase activity. Acts upstream of or within pancreas regeneration and type B pancreatic cell development. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be active in cytosol; mitochondrion; and peroxisomal matrix. Is expressed in myotome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from O'Hare et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la010267TgTransgenic insertionUnknownUnknownDNA
sa15036Allele with one point mutationUnknownPremature StopENU
sa28188Allele with one point mutationUnknownPremature StopENU
sa35572Allele with one point mutationUnknownSplice SiteENU
sa42283Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-ideN/AO'Hare et al., 2016
MO2-ideN/AO'Hare et al., 2016
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Human Disease
Associated With ide Human Ortholog
No data available
Associated With ide Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR001431 Peptidase M16, zinc-binding site
Domain IPR007863 Peptidase M16, C-terminal
Domain IPR011765 Peptidase M16, N-terminal
Domain IPR032632 Peptidase M16, middle/third domain
Domain IPR054734 Coenzyme PQQ synthesis protein F-like, C-terminal lobe, domain 4
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Domain Details Per Protein
Protein Additional Resources Length Coenzyme PQQ synthesis protein F-like, C-terminal lobe, domain 4 Metalloenzyme, LuxS/M16 peptidase-like Peptidase M16 Peptidase M16, C-terminal Peptidase M16, middle/third domain Peptidase M16, N-terminal Peptidase M16, zinc-binding site
UniProtKB:A0A0R4IL71 InterPro 998
UniProtKB:A4QP10 InterPro 978
UniProtKB:A0A8M2BGX2 InterPro 998
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 13
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ide-201 (1) Ensembl 3,973 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-11A11ZFIN Curated Data
Contained inBACCH211-129M12ZFIN Curated Data
Contained inBACDKEYP-51A12ZFIN Curated Data
EncodescDNAMGC:162603ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanIDE10
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseIde19
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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