Gene
ide
- ID
- ZDB-GENE-070410-85
- Name
- insulin-degrading enzyme
- Symbol
- ide Nomenclature History
- Previous Names
-
- zgc:162603 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within pancreas regeneration and type B pancreatic cell development. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be active in cytosol; mitochondrion; and peroxisomal matrix. Is expressed in myotome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la010267Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa15036 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa28188 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa35572 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa42283 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-ide | N/A | O'Hare et al., 2016 |
MO2-ide | N/A | O'Hare et al., 2016 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR001431 | Peptidase M16, zinc-binding site |
Domain | IPR007863 | Peptidase M16, C-terminal |
Domain | IPR011765 | Peptidase M16, N-terminal |
Domain | IPR032632 | Peptidase M16, middle/third domain |
Domain | IPR054734 | Coenzyme PQQ synthesis protein F-like, C-terminal lobe, domain 4 |
1 - 5 of 7 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | Coenzyme PQQ synthesis protein F-like, C-terminal lobe, domain 4 | Metalloenzyme, LuxS/M16 peptidase-like | Peptidase M16 | Peptidase M16, C-terminal | Peptidase M16, middle/third domain | Peptidase M16, N-terminal | Peptidase M16, zinc-binding site |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IL71 | InterPro | 998 | |||||||
UniProtKB:A4QP10 | InterPro | 978 | |||||||
UniProtKB:A0A8M2BGX2 | InterPro | 998 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-11A11 | ZFIN Curated Data | |
Contained in | BAC | CH211-129M12 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-51A12 | ZFIN Curated Data | |
Encodes | cDNA | MGC:162603 | ZFIN Curated Data |
1 - 4 of 4
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001089525 (1) | 7348 nt | ||
Genomic | GenBank:BX530089 | 176077 nt | ||
Polypeptide | UniProtKB:A0A0R4IL71 (1) | 998 aa |
- Zhu, Y., Hu, J., Zeng, S., Gao, M., Guo, S., Wang, M., Hong, Y., Zhao, G. (2023) L-selenomethionine affects liver development and glucolipid metabolism by inhibiting autophagy in zebrafish embryos. Ecotoxicology and environmental safety. 252:114589114589
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Zhang, Y., Jiao, Y., Tao, Y., Li, Z., Yu, H., Han, S., Yang, Y. (2021) Monobutyl phthalate can induce autophagy and metabolic disorders by activating the ire1a-xbp1 pathway in zebrafish liver. Journal of hazardous materials. 412:125243
- Qian, L., Zhang, J., Chen, X., Qi, S., Wu, P., Wang, C., Wang, C. (2019) Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and lipid metabolism. Environmental pollution (Barking, Essex : 1987). 247:775-782
- Qiu, L., Jia, K., Huang, L., Liao, X., Guo, X., Lu, H. (2019) Hepatotoxicity of tricyclazole in zebrafish (Danio rerio). Chemosphere. 232:171-179
- Beaudoin, J.D., Novoa, E.M., Vejnar, C.E., Yartseva, V., Takacs, C.M., Kellis, M., Giraldez, A.J. (2018) Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Nature structural & molecular biology. 25(8):677-686
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Qi, S., Liu, W., Zheng, Y. (2018) Thifluzamide affects lipid metabolism in zebrafish (Danio reio). The Science of the total environment. 633:1227-1236
- Cui, Y., Lv, S., Liu, J., Nie, S., Chen, J., Dong, Q., Huang, C., Yang, D. (2017) Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish. Human & Experimental Toxicology. 36(3):207-217
- Yang, Y., Liu, W., Li, D., Qian, L., Fu, B., Wang, C. (2017) Altered glycometabolism in zebrafish exposed to thifluzamide. Chemosphere. 183:89-96
1 - 10 of 17
Show