Gene
nox1
- ID
- ZDB-GENE-070404-1
- Name
- NADPH oxidase 1
- Symbol
- nox1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in defense response and superoxide anion generation. Predicted to be located in membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in nervous system. Orthologous to human NOX1 (NADPH oxidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nox1 | Weaver et al., 2018 | |
| CRISPR2-nox1 | Weaver et al., 2018 | |
| CRISPR3-nox1 | Martínez-Morcillo et al., 2021 | |
| MO1-nox1 | N/A | Razaghi et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013112 | FAD-binding 8 |
| Domain | IPR013121 | Ferric reductase, NAD binding domain |
| Domain | IPR013130 | Ferric reductase transmembrane component-like domain |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Family | IPR000778 | Cytochrome b245, heavy chain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome b245, heavy chain | FAD-binding 8 | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Ferric reductase, NAD binding domain | Ferric reductase transmembrane component-like domain | Respiratory burst oxidase/Ferric reductase | Riboflavin synthase-like beta-barrel |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F6NMX7 | InterPro | 564 | ||||||||
| UniProtKB:A7E3K4 | InterPro | 576 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-207K12 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-5I9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-25M22 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001102387 (1) | 1731 nt | ||
| Genomic | GenBank:CR354605 | 196530 nt | ||
| Polypeptide | UniProtKB:A7E3K4 (1) | 576 aa |
- Harijan, A.K., Kalaiarasan, R., Ghosh, A.K., Jain, R.P., Bera, A.K. (2024) The neuroprotective effect of short-chain fatty acids against hypoxia-reperfusion injury. Molecular and cellular neurosciences. 131:103972
- Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51
- Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Shanaka, K.A.S.N., Jung, S., Madushani, K.P., Kim, M.J., Lee, J. (2023) Viperin mutation is linked to immunity, immune cell dynamics, and metabolic alteration during VHSV infection in zebrafish. Frontiers in immunology. 14:13277491327749
- Maleski, A.L.A., Rosa, J.G.S., Bernardo, J.T.G., Astray, R.M., Walker, C.I.B., Lopes-Ferreira, M., Lima, C. (2022) Recapitulation of Retinal Damage in Zebrafish Larvae Infected with Zika Virus. Cells. 11(9)
- Zasu, A., Hishima, F., Thauvin, M., Yoneyama, Y., Kitani, Y., Hakuno, F., Volovitch, M., Takahashi, S.I., Vriz, S., Rampon, C., Kamei, H. (2022) NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 13:929668
- Martínez-Morcillo, F.J., Cantón-Sandoval, J., Martínez-Navarro, F.J., Cabas, I., Martínez-Vicente, I., Armistead, J., Hatzold, J., López-Muñoz, A., Martínez-Menchón, T., Corbalán-Vélez, R., Lacal, J., Hammerschmidt, M., García-Borrón, J.C., García-Ayala, A., Cayuela, M.L., Pérez-Oliva, A.B., García-Moreno, D., Mulero, V. (2021) NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. PLoS Biology. 19:e3001455
- Park, K.H., Gooz, M., Ye, Z.W., Zhang, J., Beeson, G.C., Rockey, D.C., Kim, S.H. (2021) Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish. Hepatology communications. 5:976-991
- Fang, H., Wu, X.M., Hu, Y.W., Song, Y.J., Zhang, J., Chang, M.X. (2020) NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2. Developmental and comparative immunology. 112:103769
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