Gene
nrxn3b
- ID
- ZDB-GENE-070206-10
- Name
- neurexin 3b
- Symbol
- nrxn3b Nomenclature History
- Previous Names
-
- nrxn3ba
- nrxn3bb
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within regulation of synapse maturation. Predicted to be located in membrane. Is expressed in hair cell and lateral line. Human ortholog(s) of this gene implicated in alcohol dependence and nicotine dependence. Orthologous to human NRXN3 (neurexin 3).
- Genome Resources
- Note
-
nrxn3b has two isoforms, alpha(2 forms, DQ641435 and DQ641436) and beta (DQ641437)
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013953Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021767Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021768Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021769Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028292Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7476 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa11015 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12447 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15937 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16685 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | Laminin G domain | Neurexin-related cell adhesion and synaptic protein | Neurexin/syndecan/glycophorin C | Syndecan/Neurexin domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A1XQY3 | InterPro | 675 | ||||||
| UniProtKB:A1XQY1 | InterPro | 1686 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nrxn3b-201
(1)
|
Ensembl | 4,215 nt | ||
| mRNA |
nrxn3b-202
(1)
|
Ensembl | 5,064 nt | ||
| mRNA |
nrxn3b-203
(1)
|
Ensembl | 3,077 nt | ||
| ncRNA |
nrxn3b-002
(1)
|
Ensembl | 532 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-188E4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080047 (1) | 7620 nt | ||
| Genomic | GenBank:BX088548 (2) | 152713 nt | ||
| Polypeptide | UniProtKB:A1XQY1 (1) | 1686 aa |
- Jukic, A., Lei, Z., Cebul, E.R., Pinter, K., Tadesse, Y., Jarysta, A., David, S., Mosqueda, N., Tarchini, B., Kindt, K. (2024) Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells. Development (Cambridge, England). 151(19):
- Fu, S., Tan, R., Feng, Y., Yu, P., Mo, Y., Xiao, W., Wang, S., Zhang, J. (2022) N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway. Ecotoxicology and environmental safety. 239:113674
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
- Tromp, A., Robinson, K., Hall, T.E., Mowry, B., Giacomotto, J. (2021) Pipeline for generating stable large genomic deletions in zebrafish, from small domains to whole gene excisions. G3 (Bethesda). 11(12):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lebedeva, S., de Jesus Domingues, A.M., Butter, F., Ketting, R.F. (2017) Characterization of genetic loss-of-function of Fus in zebrafish. RNA Biology. 14(1):29-35
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Shah, A.N., Davey, C.F., Whitebirch, A.C., Miller, A.C., Moens, C.B. (2015) Rapid reverse genetic screening using CRISPR in zebrafish. Nature Methods. 12(6):535-40
- Maugars, G., Dufour, S., Cohen-Tannoudji, J., Quérat, B. (2014) Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution. PLoS One. 9:e111361
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