Gene
fstl5
- ID
- ZDB-GENE-070127-1
- Name
- follistatin-like 5
- Symbol
- fstl5 Nomenclature History
- Previous Names
-
- drMahya-1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation and regulation of BMP signaling pathway. Predicted to be active in extracellular region. Is expressed in corpus cerebelli and dorsal telencephalon. Orthologous to human FSTL5 (follistatin like 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tsuchimoto et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019072Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1377 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7399 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa11024 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12250 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19099 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22550 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22551 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35761 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35762 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Kazal domain | Kazal domain superfamily | Protease Inhibitors and Growth Factor Antagonists | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DH26 | InterPro | 854 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-31E15 | ZFIN Curated Data | |
| Contained in | BAC | CH73-197L12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-89F22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-274P15 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-411A17 | ZFIN Curated Data | |
| Encodes | EST | fv45c05 | ||
| Encodes | cDNA | MGC:193924 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:136225 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001031842 (1) | 3062 nt | ||
| Genomic | GenBank:CT956065 (1) | 169875 nt | ||
| Polypeptide | UniProtKB:B3DH26 (1) | 854 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Tsuchimoto, M., Yasuo, S., Funada, M., Aoki, M., Sasagawa, H., Yoshimura, T., Tadauchi, O., Cameron, S.A., Kitagawa, Y., and Kadowaki, T. (2005) Conservation of novel Mahya genes shows the existence of neural functions common between Hymenoptera and Deuterostome. Development genes and evolution. 215(11):564-574
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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