Gene
reck
- ID
- ZDB-GENE-070117-37
- Name
- reversion-inducing-cysteine-rich protein with kazal motifs
- Symbol
- reck Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable coreceptor activity and metalloendopeptidase inhibitor activity. Acts upstream of or within several processes, including dorsal root ganglion development; regulation of canonical Wnt signaling pathway; and regulation of cell migration involved in sprouting angiogenesis. Located in plasma membrane. Is expressed in trunk and vasculature. Orthologous to human RECK (reversion inducing cysteine rich protein with kazal motifs).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13352 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| ulb3 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| w12 | Allele with one point mutation | Exon 9 - Intron 9 Splice Junction | Splice Site | ENU | |
| w13 | Allele with one point mutation | Exon 2 | Missense | ENU | |
| w14 | Allele with one point mutation | Exon 9 | Premature Stop | ENU | |
| y72 | Allele with one point mutation | Unknown | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-reck | Parab et al., 2023 | |
| MO1-reck | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002350 | Kazal domain |
| Domain | IPR055110 | Reversion-inducing cysteine-rich with Kazal motifs, N-terminal |
| Domain | IPR055134 | RECK, EGF-like 2 domain |
| Family | IPR039016 | Reversion-inducing cysteine-rich protein with Kazal motifs |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Kazal domain | Kazal domain superfamily | RECK, EGF-like 2 domain | Reversion-inducing cysteine-rich protein with Kazal motifs | Reversion-inducing cysteine-rich with Kazal motifs, N-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13ABN5 | InterPro | 955 | |||||
| UniProtKB:A0A0R4IKU3 | InterPro | 955 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-59L16 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-416F3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423853 (1) | 4331 nt | ||
| Genomic | GenBank:FP565452 (2) | 38930 nt | ||
| Polypeptide | UniProtKB:A0A0R4IKU3 (1) | 955 aa |
- Comparative Orthology
- Alliance
- Parab, S., Card, O.A., Chen, Q., America, M., Buck, L.D., Quick, R.E., Horrigan, W.F., Levkowitz, G., Vanhollebeke, B., Matsuoka, R.L. (2023) Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries. eLIFE. 12:
- Xu, Y., Luo, L., Chen, J. (2022) Sulfamethoxazole induces brain capillaries toxicity in zebrafish by up-regulation of VEGF and chemokine signalling. Ecotoxicology and environmental safety. 238:113620
- Kumari, R., Silic, M.R., Jones-Hall, Y.L., Nin-Velez, A., Yang, J.Y., Mittal, S.K., Zhang, G. (2018) Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors.. Oncotarget. 9:23494-23504
- Bostaille, N., Gauquier, A., Twyffels, L., Vanhollebeke, B. (2016) Molecular insights into Adgra2/Gpr124 and Reck intracellular trafficking. Biology Open. 5:1874-1881
- Ulrich, F., Carretero-Ortega, J., Menéndez, J., Narvaez, C., Sun, B., Lancaster, E., Pershad, V., Trzaska, S., Véliz, E., Kamei, M., Prendergast, A., Kidd, K.R., Shaw, K.M., Castranova, D.A., Pham, V.N., Lo, B.D., Martin, B.L., Raible, D.W., Weinstein, B.M., Torres-Vazquez, J. (2016) Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development (Cambridge, England). 143(1):147-59
- Ulrich, F., Grove, C., Torres-Vázquez, J., Baker, R. (2016) Development of functional hindbrain oculomotor circuitry independent of both vascularization and neuronal activity in larval zebrafish. Current Neurobiology. 7:62-73
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Vanhollebeke, B., Stone, O.A., Bostaille, N., Cho, C., Zhou, Y., Maquet, E., Gauquier, A., Cabochette, P., Fukuhara, S., Mochizuki, N., Nathans, J., Stainier, D.Y. (2015) Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. eLIFE. 4
- Leigh, N.R., Schupp, M.O., Li, K., Padmanabhan, V., Gastonguay, A., Wang, L., Chun, C.Z., Wilkinson, G.A., and Ramchandran, R. (2013) Mmp17b is essential for proper neural crest cell migration in vivo. PLoS One. 8(10):e76494
- Malmquist, S.J., Abramsson, A., McGraw, H.F., Linbo, T.H., Raible, D.W. (2013) Modulation of dorsal root ganglion development by ErbB signaling and the scaffold protein Sorbs3. Development (Cambridge, England). 140:3986-3996
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