Gene
dctn1a
- ID
- ZDB-GENE-070117-2205
- Name
- dynactin 1a
- Symbol
- dctn1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity. Acts upstream of or within several processes, including apical protein localization; nuclear migration; and retina morphogenesis in camera-type eye. Predicted to be located in cell cortex and microtubule cytoskeleton. Predicted to be part of microtubule associated complex. Predicted to be active in axon; kinetochore; and spindle pole. Is expressed in head; muscle; nervous system; presumptive neural retina; and trunk. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
m632 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
s309 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa14467 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40818 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
y625 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-dctn1a | (4) | |
MO1-dctn1a | N/A | Tsujikawa et al., 2007 |
MO2-dctn1a | N/A | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
amyotrophic lateral sclerosis type 1 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to} | 105400 |
autosomal dominant distal hereditary motor neuronopathy 14 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 14 | 607641 |
Perry syndrome | Alliance | Perry syndrome | 168605 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | CAP Gly-rich domain | CAP Gly-rich domain superfamily | Dynein associated protein |
---|---|---|---|---|---|
UniProtKB:Q07DR3 | InterPro | 1218 | |||
UniProtKB:A0A8M9Q1C7 | InterPro | 1232 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
dctn1a-201
(1)
|
Ensembl | 8,004 nt | ||
mRNA |
dctn1a-202
(1)
|
Ensembl | 3,777 nt | ||
mRNA |
dctn1a-203
(1)
|
Ensembl | 4,304 nt | ||
mRNA |
dctn1a-204
(1)
|
Ensembl | 4,421 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-31G16 | ZFIN Curated Data | |
Contained in | BAC | DKEY-162H11 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001077212 (1) | 3825 nt | ||
Genomic | GenBank:CT030017 (1) | 178250 nt | ||
Polypeptide | UniProtKB:A0A8M9Q1C7 (1) | 1232 aa |
- Kawano, D., Pinter, K., Chlebowski, M., Petralia, R.S., Wang, Y.X., Nechiporuk, A.V., Drerup, C.M. (2022) NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals. iScience. 25:105072105072
- Cao, Z., Su, M., Wang, H., Zhou, L., Meng, Z., Xiong, G., Liao, X., Lu, H. (2020) Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae. Chemosphere. 270:128611
- Mandal, A., Wong, H.C., Pinter, K., Mosqueda, N., Beirl, A., Lomash, R.M., Won, S., Kindt, K.S., Drerup, C.M. (2020) Retrograde mitochondrial transport is essential for organelle distribution and health in zebrafish neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(7):1371-1392
- Zhang, X., Zhou, Q., Li, X., Zou, W., Hu, X. (2020) Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Environmental pollution (Barking, Essex : 1987). 263:114473
- Bercier, V., Hubbard, J.M., Fidelin, K., Duroure, K., Auer, T.O., Revenu, C., Wyart, C., Del Bene, F. (2019) Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities. Molecular neurodegeneration. 14:27
- Laboissonniere, L.A., Smith, C.L., Mesenbrink, J., Chowdhury, R., Burney, A., Lang, M., Sierra, M., Stark, A., Maldonado-Casalduc, G., Muller, M., Trimarchi, J.M. (2018) ALS-associated genes display CNS expression in the developing zebrafish. Gene expression patterns : GEP. 30:14-31
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Drerup, C.M., Herbert, A.L., Monk, K.R., Nechiporuk, A.V. (2017) Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Insinna, C., Baye, L.M., Amsterdam, A., Besharse, J.C., and Link, B.A. (2010) Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. Neural Development. 5:12
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