Gene
ift70
- ID
- ZDB-GENE-070117-2066
- Name
- intraflagellar transport 70
- Symbol
- ift70 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables tubulin-glycine ligase activity. Involved in intraciliary transport and protein polyglutamylation. Acts upstream of or within several processes, including cilium assembly; determination of left/right symmetry; and opsin transport. Located in axonemal microtubule and motile cilium. Is expressed in Kupffer's vesicle; lateral mesoderm; nervous system; and pronephros. Orthologous to human IFT70A (intraflagellar transport 70A) and IFT70B (intraflagellar transport 70B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la028891Tg | Transgenic insertion | Unknown | Unknown | DNA | |
m477 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40077 | Allele with one point mutation | Unknown | Missense, Premature Stop | ENU | |
tpl19Gt | Transgenic insertion | Intron 1 | Unknown | DNA | |
tpl19RGt | Transgenic insertion | Unknown | Unknown | DNA | |
tpl141Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
zf359 | Allele with one point mutation | Unknown | Unknown | not specified |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-ift70 | Burg et al., 2018 | |
MO1-ift70 | N/A | (2) |
MO2-ift70 | N/A | Pathak et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR039941 | Tetratricopeptide repeat protein 30 |
Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
Homologous_superfamily | IPR036723 | Alpha-catenin/vinculin-like superfamily |
Repeat | IPR013105 | Tetratricopeptide repeat 2 |
Repeat | IPR019734 | Tetratricopeptide repeat |
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Domain Details Per Protein
Protein | Additional Resources | Length | Alpha-catenin/vinculin-like superfamily | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | Tetratricopeptide repeat 2 | Tetratricopeptide repeat protein 30 |
---|---|---|---|---|---|---|---|
UniProtKB:A7YE96 | InterPro | 651 | |||||
UniProtKB:A0A8M9PR90 | InterPro | 575 | |||||
UniProtKB:A0A8M9P934 | InterPro | 645 | |||||
UniProtKB:A0A8M9PYI9 | InterPro | 667 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-76L23 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195339 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001104649 (1) | 2556 nt | ||
Genomic | GenBank:BX510989 (1) | 169229 nt | ||
Polypeptide | UniProtKB:A0A8M9PYI9 (1) | 667 aa |
No data available
- Burg, L., Palmer, N., Kikhi, K., Miroshnik, E.S., Rueckert, H., Gaddy, E., MacPherson Cunningham, C., Mattonet, K., Lai, S.L., Marín-Juez, R., Waring, R.B., Stainier, D.Y.R., Balciunas, D. (2018) Conditional mutagenesis by oligonucleotide-mediated integration of loxP sites in zebrafish. PLoS Genetics. 14:e1007754
- Pooranachandran, N., Malicki, J.J. (2016) Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins. Genetics. 203(2):771-85
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Pathak, N., Austin-Tse, C.A., Liu, Y., Vasilyev, A., Drummond, I.A. (2014) Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. Molecular biology of the cell. 25(12):1836-44
- Balciuniene, J., Nagelberg, D., Walsh, K., Camerota, D., Georlette, D., Biemar, F., Bellipanni, G., and Balciunas, D. (2013) Efficient disruption of Zebrafish genes using a Gal4-containing gene trap. BMC Genomics. 14(1):619
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Leshchiner, I., Alexa, K., Kelsey, P., Adzhubei, I., Austin, C., Cooney, J., Anderson, H., King, M., Stottman, R., Ha, S., Drummond, I., Paw, B.H., North, T., Beier, D., Goessling, W., and Sunyaev, S. (2012) Mutation mapping and identification by whole genome sequencing. Genome research. 22(8):1541-1548
- Pathak, N., Austin, C.A., and Drummond, I.A. (2011) Tubulin tyrosine ligase like genes TTLL3 and TTLL6 maintain zebrafish cilia structure and motility. The Journal of biological chemistry. 286(13):11685-11695
- Zhao, C., and Malicki, J. (2011) Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. The EMBO journal. 30(13):2532-2544
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