Gene
aifm4
- ID
- ZDB-GENE-070112-2282
- Name
- apoptosis inducing factor mitochondria associated 4
- Symbol
- aifm4 Nomenclature History
- Previous Names
-
- zgc:158614 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable oxidoreductase activity, acting on NAD(P)H. Is expressed in head.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chen et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR017941 | Rieske [2Fe-2S] iron-sulphur domain |
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Domain | IPR028202 | Reductase, C-terminal |
| Family | IPR050446 | FAD-dependent Oxidoreductases and Apoptosis Regulators |
| Homologous_superfamily | IPR016156 | FAD/NAD-linked reductase, dimerisation domain superfamily |
1 - 5 of 7 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-dependent Oxidoreductases and Apoptosis Regulators | FAD/NAD-linked reductase, dimerisation domain superfamily | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily | Reductase, C-terminal | Rieske [2Fe-2S] iron-sulphur domain | Rieske [2Fe-2S] iron-sulphur domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B3R9 | InterPro | 530 | |||||||
| UniProtKB:A1L230 | InterPro | 455 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-54N8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158614 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001431153 (1) | 1979 nt | ||
| Genomic | GenBank:CU856359 (1) | 143377 nt | ||
| Polypeptide | UniProtKB:A0A8M2B3R9 (1) | 530 aa |
No data available
- Chen, X.K., Kwan, J.S., Wong, G.T., Yi, Z.N., Ma, A.C., Chang, R.C. (2022) Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio). Experimental & molecular medicine. 54(7):973-987
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Ng, P.C.I., Chan, J.Y.W., Leung, R.K.K., Li, J., Ren, Z., Chan, A.W.H., Xu, Y., Lee, S.S., Wang, R., Ji, X., Zheng, J., Chan, D.P.C., Yew, W.W., Lee, S.M.Y. (2020) Role of oxidative stress in clofazimine-induced cardiac dysfunction in a zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 132:110749
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Driessen, M., Kienhuis, A.S., Vitins, A.P., Pennings, J.L., Pronk, T.E., Brandhof, E.J., Roodbergen, M., Water, B.V., Ven, L.T. (2014) Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Toxicology letters. 230(1):48-56
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 6 of 6
Show