Gene
kdm6al
- ID
- ZDB-GENE-070112-2002
- Name
- lysine (K)-specific demethylase 6A, like
- Symbol
- kdm6al Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Acts upstream of or within several processes, including anterior/posterior pattern specification; germ cell migration; and heart development. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Is expressed in blood island and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029267Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kdm6al | (4) | |
| CRISPR2-kdm6al | Gagnon et al., 2014 | |
| MO1-kdm6al | N/A | (3) |
| MO2-kdm6al | N/A | (3) |
| MO3-kdm6al | N/A | Van Laarhoven et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003347 | JmjC domain |
| Domain | IPR048560 | Lysine-specific demethylase 6A/B-like, GATA-like |
| Domain | IPR048562 | Lysine-specific demethylase 6A/B-like, C-terminal helical domain |
| Family | IPR051630 | Transcriptional Corepressor and Histone Demethylase |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | JmjC domain | Lysine-specific demethylase 6A/B-like, C-terminal helical domain | Lysine-specific demethylase 6A/B-like, GATA-like | Lysine-specific demethylase 6, GATA-like domain superfamily | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | Transcriptional Corepressor and Histone Demethylase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A1L1S9 | InterPro | 1311 | |||||||
| UniProtKB:A0A8M2BG42 | InterPro | 1356 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
kdm6al-203
(1)
|
Ensembl | 5,865 nt | ||
| mRNA |
kdm6al-201
(1)
|
Ensembl | 4,921 nt | ||
| ncRNA |
kdm6al-003
(1)
|
Ensembl | 208 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-158D14 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-389C18 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-441H10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158313 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080193 (1) | 4954 nt | ||
| Genomic | GenBank:CU855795 (1) | 37498 nt | ||
| Polypeptide | UniProtKB:A0A8M2BG42 (1) | 1356 aa |
No data available
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Fellous, A., Earley, R.L., Silvestre, F. (2018) The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 687:173-187
- Wu, X., Shen, W., Zhang, B., Meng, A. (2018) The genetic program of oocytes can be modified in vivo in the zebrafish ovary. Journal of molecular cell biology. 10(6):479-493
- Yu, S.H., Zhu, K.Y., Zhang, F., Wang, J., Yuan, H., Chen, Y., Jin, Y., Dong, M., Wang, L., Jia, X.E., Gao, L., Dong, Z.W., Ren, C.G., Chen, L.T., Huang, Q.H., Deng, M., Zon, L.I., Zhou, Y., Zhu, J., Xu, P.F., Liu, T.X. (2018) The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochimica et biophysica acta. 1861(2):106-116
- Akerberg, A.A., Henner, A., Stewart, S., Stankunas, K. (2017) Histone demethylases Kdm6ba and Kdm6bb redundantly promote cardiomyocyte proliferation during zebrafish heart ventricle maturation. Developmental Biology. 426(1):84-96
- Burger, A., Lindsay, H., Felker, A., Hess, C., Anders, C., Chiavacci, E., Zaugg, J., Weber, L.M., Catena, R., Jinek, M., Robinson, M.D., Mosimann, C. (2016) Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Development (Cambridge, England). 143(11):2025-37
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Van Laarhoven, P.M., Neitzel, L.R., Quintana, A.M., Geiger, E.A., Zackai, E.H., Clouthier, D.E., Artinger, K.B., Ming, J.E., Shaikh, T.H. (2015) Kabuki syndrome genes KMT2D and KDM6A: functional analyses demonstrate critical roles in craniofacial, heart, and brain development. Human molecular genetics. 24(15):4443-53
- Gagnon, J.A., Valen, E., Thyme, S.B., Huang, P., Ahkmetova, L., Pauli, A., Montague, T.G., Zimmerman, S., Richter, C., Schier, A.F. (2014) Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs. PLoS One. 9:e98186
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