Gene

cyp21a2

ID
ZDB-GENE-070103-6
Name
cytochrome P450, family 21, subfamily A, polypeptide 2
Symbol
cyp21a2 Nomenclature History
Previous Names
  • cyp21a1 (1)
  • si:ch1073-443n13.1
  • si:ch211-257p13.4
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable heme binding activity and steroid 21-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in brain; gonad primordium; head; head kidney; and interrenal primordium. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human CYP21A2 (cytochrome P450 family 21 subfamily A member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Eachus et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
uob2122Allele with one deletionUnknownFrameshift, Premature StopTALEN
uob2123Allele with one deletionUnknownFrameshift, Premature StopTALEN
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
TALEN1-cyp21a2Eachus et al., 2017
1 - 1 of 1
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Human Disease
Associated With cyp21a2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital adrenal hyperplasia Alliance Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 201910
congenital adrenal hyperplasia Alliance Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency 201910
1 - 2 of 2
Associated With cyp21a2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
1 - 4 of 4
Domain Details Per Protein
Protein Additional Resources Length Cytochrome P450 Cytochrome P450, conserved site Cytochrome P450, E-class, group I Cytochrome P450 superfamily
UniProtKB:A0A8M9NZM6 InterPro 522
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 16
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cyp21a2-201 (1) Ensembl 1,828 nt
mRNA cyp21a2-202 (1) Ensembl 3,078 nt
mRNA cyp21a2-203 (1) Ensembl 3,177 nt
mRNA cyp21a2-204 (1) Ensembl 2,991 nt
1 - 4 of 4
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-207C13
Contained inBACCH211-257P13ZFIN Curated Data
Contained inFosmidCH1073-443N13ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCYP21A26
Conserved genome location (synteny) (1)
Nucleotide sequence comparison (1)
Amino acid sequence comparison (2)
MouseCyp21a117
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
1 - 10 of 16
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