Gene

adnpa

ID
ZDB-GENE-061215-112
Name
activity-dependent neuroprotector homeobox a
Symbol
adnpa Nomenclature History
Previous Names
  • adnp1a (1)
  • wu:fi35b06
  • zgc:154063
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Enables beta-catenin binding activity. Involved in regulation of neurogenesis. Acts upstream of or within Wnt signaling pathway; dorsal/ventral axis specification; and erythrocyte maturation. Located in cytoplasm and nucleus. Is expressed in eye; forebrain; midbrain; and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in Helsmoortel-Van Der Aa Syndrome. Orthologous to human ADNP (activity dependent neuroprotector homeobox).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Dresner et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb804Allele with one deletionUnknownUnknownCRISPR
sa18289Allele with one point mutationUnknownPremature StopENU
sa21912Allele with one point mutationUnknownPremature StopENU
sa31831Allele with one point mutationUnknownPremature StopENU
sa35089Allele with one point mutationUnknownPremature StopENU
sa45430Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-adnpaSun et al., 2020
MO1-adnpaN/ADresner et al., 2012
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Human Disease
Associated With adnpa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Helsmoortel-Van Der Aa Syndrome Alliance Helsmoortel-van der Aa syndrome 615873
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Associated With adnpa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeodomain
Domain IPR013087 Zinc finger C2H2-type
Domain IPR045762 ADNP, zinc finger domain
Family IPR038861 Activity-dependent neuroprotector homeobox protein
Homologous_superfamily IPR009057 Homedomain-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length Activity-dependent neuroprotector homeobox protein ADNP, zinc finger domain Homedomain-like superfamily Homeodomain Zinc finger C2H2-type
UniProtKB:F1QLG5 InterPro 969
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 11
Type Name Annotation Method Has Havana Data Length (nt) Analysis
antisense ottdart00000060066 (1) Ensembl 6,057 nt
mRNA adnpa-201 (1) Ensembl 3,637 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-232B12ZFIN Curated Data
Contained inBACDKEY-29P20
Contained inBACDKEYP-97E7ZFIN Curated Data
EncodesESTfi35b06
EncodescDNAMGC:154063ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanADNP20
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseAdnp2
Amino acid sequence comparison (1)
Citations
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