Gene
adnpa
- ID
- ZDB-GENE-061215-112
- Name
- activity-dependent neuroprotector homeobox a
- Symbol
- adnpa Nomenclature History
- Previous Names
-
- adnp1a (1)
- wu:fi35b06
- zgc:154063
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables beta-catenin binding activity. Involved in regulation of neurogenesis. Acts upstream of or within Wnt signaling pathway; dorsal/ventral axis specification; and erythrocyte maturation. Located in cytoplasm and nucleus. Is expressed in eye; forebrain; midbrain; and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in Helsmoortel-Van Der Aa Syndrome. Orthologous to human ADNP (activity dependent neuroprotector homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Dresner et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ihb804 | Allele with one deletion | Unknown | Unknown | CRISPR | |
sa18289 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21912 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa31831 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa35089 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa45430 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-adnpa | Sun et al., 2020 | |
MO1-adnpa | N/A | Dresner et al., 2012 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Helsmoortel-Van Der Aa Syndrome | Alliance | Helsmoortel-van der Aa syndrome | 615873 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Activity-dependent neuroprotector homeobox protein | ADNP, zinc finger domain | Homedomain-like superfamily | Homeodomain | Zinc finger C2H2-type |
---|---|---|---|---|---|---|---|
UniProtKB:F1QLG5 | InterPro | 969 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
antisense |
ottdart00000060066
(1)
|
Ensembl | 6,057 nt | ||
mRNA |
adnpa-201
(1)
|
Ensembl | 3,637 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-232B12 | ZFIN Curated Data | |
Contained in | BAC | DKEY-29P20 | ||
Contained in | BAC | DKEYP-97E7 | ZFIN Curated Data | |
Encodes | EST | fi35b06 | ||
Encodes | cDNA | MGC:154063 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001080015 (1) | 3658 nt | ||
Genomic | GenBank:AL974308 | 180511 nt | ||
Polypeptide | UniProtKB:F1QLG5 (1) | 969 aa |
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Sun, X., Peng, X., Cao, Y., Zhou, Y., Sun, Y. (2020) ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling. Nature communications. 11:2984
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Nachtigall, P., Dias, M., Pinhal, D. (2014) Evolution and genomic organization of muscle microRNAs in fish genomes. BMC Evolutionary Biology. 14:196
- Dresner, E., Malishkevich, A., Arviv, C., Leibman Barak, S., Alon, S., Ofir, R., Gothilf, Y., and Gozes, I. (2012) Novel Evolutionary-Conserved Role for the ADNP Protein Family that is Important for Erythropoiesis. The Journal of biological chemistry. 287(48):40173-40185
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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