Gene

bcl11ba

ID
ZDB-GENE-061207-62
Name
BCL11 transcription factor B a
Symbol
bcl11ba Nomenclature History
Previous Names
  • bcl11b.1 (1)
  • bcl11b
  • si:dkey-238i13.1
  • wu:fj43a03
  • zgc:165628 (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of SWI/SNF complex. Predicted to be active in nucleus. Is expressed in thymus. Human ortholog(s) of this gene implicated in immunodeficiency 49. Orthologous to human BCL11B (BCL11 transcription factor B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
a238Allele with one deletionUnknownUnknownCRISPR
la019962TgTransgenic insertionUnknownUnknownDNA
la027819TgTransgenic insertionUnknownUnknownDNA
mn0240GtTransgenic insertionUnknownUnknownDNA
sa2902Allele with one point mutationUnknownPremature StopENU
sa6468Allele with one point mutationUnknownPremature StopENU
sa16831Allele with one point mutationUnknownPremature StopENU
sa23039Allele with one point mutationUnknownSplice SiteENU
sa36375Allele with one point mutationUnknownPremature StopENU
uab448Allele with one deletionIntron 2UnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-bcl11baThyme et al., 2019
MO1-bcl11baN/A (2)
MO2-bcl11baN/A (2)
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Human Disease
Associated With bcl11ba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 49 Alliance Immunodeficiency 49, severe combined 617237
Intellectual developmental disorder with dysmorphic facies, speech delay, and T-cell abnormalities 618092
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Associated With bcl11ba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Domain IPR056438 CTCF-like, C2H2 zinc finger
Family IPR051497 Developmental and Hematopoietic Transcription Factors
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
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Domain Details Per Protein
Protein Additional Resources Length CTCF-like, C2H2 zinc finger Developmental and Hematopoietic Transcription Factors Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:A0A2R8Q8A6 InterPro 814
UniProtKB:A0A8M3AR85 InterPro 813
UniProtKB:X1WBZ3 InterPro 776
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA bcl11ba-202 (1) Ensembl 1,065 nt
mRNA bcl11ba-203 (1) Ensembl 3,240 nt
mRNA bcl11ba-204 (1) Ensembl 6,099 nt
mRNA bcl11ba-205 (1) Ensembl 8,016 nt
ncRNA bcl11ba-003 (1) Ensembl 543 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-262A18ZFIN Curated Data
Contained inBACDKEY-238I13ZFIN Curated Data
EncodesESTfj43a03
EncodescDNAMGC:165628ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanBCL11B14
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseBcl11b12
Amino acid sequence comparison (1)
Citations
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