Gene
tuba1c
- ID
- ZDB-GENE-061114-1
- Name
- tubulin, alpha 1c
- Symbol
- tuba1c Nomenclature History
- Previous Names
-
- tuba1l
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in nervous system and skeletal muscle. Orthologous to human TUBA1C (tubulin alpha 1c).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Oocyte/zygote/embryo maturation arrest 24 | 621232 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha tubulin | Tubulin | Tubulin, conserved site | Tubulin, C-terminal | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain superfamily | Tubulin/FtsZ-like, C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A518 | InterPro | 451 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tuba1c-201
(1)
|
Ensembl | 1,682 nt | ||
| mRNA |
tuba1c-202
(1)
|
Ensembl | 1,720 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-18F23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55332 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171407 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192906 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001105126 (1) | 1682 nt | ||
| Genomic | GenBank:BX465853 (2) | 220945 nt | ||
| Polypeptide | UniProtKB:B8A518 (1) | 451 aa |
- Zhang, Y., Liu, Y., Qin, W., Zheng, S., Xiao, J., Xia, X., Yuan, X., Zeng, J., Shi, Y., Zhang, Y., Ma, H., Varshney, G.K., Fei, J.F., Liu, Y. (2024) Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish. Nature communications. 15:95269526
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Chin, J.S.R., Phan, T.N., Albert, L.T., Keene, A.C., Duboué, E.R. (2022) Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish. Scientific Reports. 12:12826
- Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Chen, X., Guo, W., Lei, L., Guo, Y., Yang, L., Han, J., Zhou, B. (2020) Bioconcentration and developmental neurotoxicity of novel brominated flame retardants, hexabromobenzene and pentabromobenzene in zebrafish. Environmental pollution (Barking, Essex : 1987). 268:115895
- Rassier, G.T., Silveira, T.L.R., Remião, M.H., Daneluz, L.O., Martins, A.W.S., Dellagostin, E.N., Ortiz, H.G., Domingues, W.B., Komninou, E.R., Kütter, M.T., Marins, L.F.F., Campos, V.F. (2020) Evaluation of qPCR reference genes in GH-overexpressing transgenic zebrafish (Danio rerio). Scientific Reports. 10:12692
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Shir-Mohammadi, K., Perry, S.F. (2020) Expression of ion-transport genes in ionocytes isolated from larval zebrafish (Danio rerio) exposed to acidic or Na+ deficient water. American journal of physiology. Regulatory, integrative and comparative physiology. 319(4):R412-R427
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