Gene
agap2
- ID
- ZDB-GENE-061103-343
- Name
- ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
- Symbol
- agap2 Nomenclature History
- Previous Names
-
- lnc.punisher (1)
- zgc:153779
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity and GTPase activity. Acts upstream of or within with a positive effect on heart development and vasculature development. Predicted to be active in cytoplasm; membrane; and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kurian et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kurian et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001164 | Arf GTPase activating protein |
Domain | IPR001849 | Pleckstrin homology domain |
Family | IPR001806 | Small GTPase |
Family | IPR051282 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein |
Homologous_superfamily | IPR011993 | PH-like domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | ArfGAP domain superfamily | ARFGAP/RecO-like zinc finger | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein | Arf GTPase activating protein | PH-like domain superfamily | Pleckstrin homology domain | P-loop containing nucleoside triphosphate hydrolase | Small GTPase |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3AVN4 | InterPro | 1082 | ||||||||||
UniProtKB:A0A8M3AN70 | InterPro | 847 | ||||||||||
UniProtKB:A0JMI1 | InterPro | 827 | ||||||||||
UniProtKB:A0A8M3AYQ6 | InterPro | 1110 | ||||||||||
UniProtKB:A0A8M3ANW4 | InterPro | 1130 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Kurian, L., Aguirre, A., Sancho-Martinez, I., Benner, C., Hishida, T., Nguyen, T.B., Reddy, P., Nivet, E., Krause, M.N., Nelles, D.A., Rodriguez Esteban, C., Campistol, J.M., Yeo, G.W., Izpisua Belmonte, J.C. (2015) Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. Circulation. 131:1278-90
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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