Gene
irg1l
- ID
- ZDB-GENE-061103-301
- Name
- immunoresponsive gene 1, like
- Symbol
- irg1l Nomenclature History
- Previous Names
-
- fc49d01
- wu:fc49d01
- zgc:154020
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable aconitate decarboxylase activity. Acts upstream of or within inflammatory response to wounding and response to bacterium. Predicted to be active in mitochondrion. Is expressed in digestive system; head; and male organism. Orthologous to human ACOD1 (aconitate decarboxylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | MmgE/PrpD | MmgE/PrpD, C-terminal | MmgE/PrpD, N-terminal | MmgE/PrpD superfamily | MmgE/PrpD superfamily, domain 1 | MmgE/PrpD superfamily, domain 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0JMM8 | InterPro | 498 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-153B23 | ZFIN Curated Data | |
| Encodes | EST | fc49d01 | ||
| Encodes | cDNA | MGC:154020 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077607 (1) | 1991 nt | ||
| Genomic | GenBank:CR381540 (1) | 167095 nt | ||
| Polypeptide | UniProtKB:A0JMM8 (1) | 498 aa |
No data available
- Sebo, D.J., Ali, I., Fetsko, A.R., Trimbach, A.A., Taylor, M.R. (2025) Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation. Scientific Reports. 15:34963496
- McCann, T., Sundaramurthi, H., Walsh, C., Virdi, S., Alvarez, Y., Sapetto-Rebow, B., Collery, R.F., Carter, S.P., Moran, A., Mulholland, R., O'Connor, J.J., Taylor, M.R., Rauch, N., Starostik, M.R., English, M.A., Swaroop, A., Geisler, R., Reynolds, A.L., Kennedy, B.N. (2024) Emc1 is essential for vision and zebrafish photoreceptor outer segment morphogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e70086e70086
- Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51
- Luckner, B., Essfeld, F., Ayobahan, S.U., Richling, E., Eilebrecht, E., Eilebrecht, S. (2023) Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression. Ecotoxicology and environmental safety. 266:115570115570
- Atienzar-Aroca, R., Aroca-Aguilar, J.D., Alexandre-Moreno, S., Ferre-Fernández, J.J., Bonet-Fernández, J.M., Cabañero-Varela, M.J., Escribano, J. (2021) Knockout of myoc Provides Evidence for the Role of Myocilin in Zebrafish Sex Determination Associated with Wnt Signalling Downregulation. Biology. 10(2):
- Larbalestier, H., Keatinge, M., Watson, L., White, E., Gowda, S., Wei, W., Koler, K., Semenova, S.A., Elkin, A.M., Rimmer, N., Sweeney, S.T., Mazzolini, J., Sieger, D., Hide, W., McDearmid, J., Panula, P., MacDonald, R.B., Bandmann, O. (2021) GCH1 deficiency activates brain innate immune response and impairs tyrosine hydroxylase homeostasis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(4):702-716
- Nowik, N., Prajsnar, T.K., Przyborowska, A., Rakus, K., Sienkiewicz, W., Spaink, H.P., Podlasz, P. (2021) The Role of Galanin during Bacterial Infection in Larval Zebrafish. Cells. 10(8):
- Valenzuela, L., Pacheco, S., Rincón, G., Pavez, L., Lam, N., Hernández, A.J., Dantagnan, P., González, F., Jilberto, F., Ravanal, M.C., Ramos, C., Garcia, H., Araneda, C., Ulloa, P.E. (2021) Intestinal Transcriptome Analysis Reveals Enrichment of Genes Associated with Immune and Lipid Mechanisms, Favoring Soybean Meal Tolerance in High-Growth Zebrafish (Danio Rerio). Genes. 12(5):
- Gans, I., Hartig, E.I., Zhu, S., Tilden, A.R., Hutchins, L.N., Maki, N.J., Graber, J.H., Coffman, J.A. (2020) Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Scientific Reports. 10:11415
- Schmid, S., Willi, R.A., Fent, K. (2020) Effects of environmental steroid mixtures are regulated by individual steroid receptor signaling. Aquatic toxicology (Amsterdam, Netherlands). 226:105562
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