Gene
foxo1a
- ID
- ZDB-GENE-061013-59
- Name
- forkhead box O1 a
- Symbol
- foxo1a Nomenclature History
- Previous Names
-
- foxo1
- foxo1a.1 (1)
- zgc:153388
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a positive effect on gluconeogenesis. Acts upstream of or within several processes, including lymph vessel development; smooth muscle cell proliferation; and smooth muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in digestive system; head mesenchyme; pericardial region; pharyngeal arch; and skeletal muscle. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gays et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-foxo1a | (2) | |
| CRISPR2-foxo1a | Zebrafish Nomenclature Committee | |
| CRISPR3-foxo1a | Zebrafish Nomenclature Committee | |
| MO1-foxo1a | N/A | Kiesow et al., 2015 |
| MO2-foxo1a | N/A | Gays et al., 2017 |
| MO3-foxo1a | N/A | Gays et al., 2017 |
| MO4-foxo1a | N/A | Gays et al., 2017 |
| MO5-foxo1a | N/A | Gays et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alveolar rhabdomyosarcoma | Alliance | Rhabdomyosarcoma, alveolar | 268220 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein O1, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXO protein, KIX-binding domain | FOXO protein, transactivation domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A3RK74 | InterPro | 652 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxo1a-201
(1)
|
Ensembl | 5,915 nt | ||
| mRNA |
foxo1a-202
(1)
|
Ensembl | 1,959 nt | ||
| mRNA |
foxo1a-203
(1)
|
Ensembl | 1,146 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-203F4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153388 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077257 (1) | 1959 nt | ||
| Genomic | GenBank:BX649258 (1) | 148199 nt | ||
| Polypeptide | UniProtKB:A3RK74 (1) | 652 aa |
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Wang, X., Kang, X., Li, B., Chen, C., Chen, L., Liu, D. (2025) High Glucose Treatment Induces Nuclei Aggregation of Microvascular Endothelial Cells via the foxo1a-klf2a Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. :
- Benchoula, K., Serpell, C.J., Mediani, A., Albogami, A., Misnan, N.M., Ismail, N.H., Parhar, I.S., Ogawa, S., Hwa, W.E. (2024) 1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene. Scientific Reports. 14:38233823
- Liu, K., Zhu, Y., Gao, W., Han, X., Zhang, Q., Zhao, Y., Zu, Y. (2024) Resveratrol alleviates heart failure by activating foxo3a to counteract oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 181:117716117716
- Pan, S.W., Wang, H.D., Hsiao, H.Y., Hsu, P.J., Tseng, Y.C., Liang, W.C., Jong, Y.J., Yuh, C.H. (2024) Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish. Scientific Reports. 14:1282612826
- Wang, X., Zhao, J., Xu, J., Li, B., Liu, X., Xie, G., Duan, X., Liu, D. (2024) Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal. eLIFE. 13:
- Ikeda, D., Fujita, S., Toda, K., Yaginuma, Y., Kan-No, N., Watabe, S. (2023) Cold-induced muscle atrophy in zebrafish: Insights from swimming activity and gene expression analysis. Biochemistry and biophysics reports. 36:101570101570
- Xu, H., Mao, X., Nie, Z., Li, Y. (2023) Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free radical biology & medicine. 203:102-113
- Rawson, A., Saxena, V., Gao, H., Hooks, J., Xuei, X., McGuire, P., Hato, T., Hains, D.S., Anderson, R.M., Schwaderer, A.L. (2022) A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection. Pathogens & immunity. 7:1-18
- Meng, Y., Zhong, K., Chen, S., Huang, Y., Wei, Y., Wu, J., Liu, J., Xu, Z., Guo, J., Liu, F., Lu, H. (2021) Cardiac toxicity assessment of pendimethalin in zebrafish embryos. Ecotoxicology and environmental safety. 222:112514
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