Gene
sfrp2
- ID
- ZDB-GENE-061013-293
- Name
- secreted frizzled-related protein 2
- Symbol
- sfrp2 Nomenclature History
- Previous Names
-
- hm:zeh0225
- sb:eu233
- zeh0225
- zgc:153618
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway and cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adaxial cell; axis; ectoderm; head; and musculature system. Orthologous to human SFRP2 (secreted frizzled related protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu233 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhu et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sfrp2 | Askary et al., 2017 | |
| CRISPR2-sfrp2 | Askary et al., 2017 | |
| MO1-sfrp2 | N/A | Ebarasi et al., 2009 |
| MO2-sfrp2 | N/A | Ahmed et al., 2017 |
| MO3-sfrp2 | N/A | Ahmed et al., 2017 |
| MO4-sfrp2 | N/A | Zhu et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Netrin domain | Netrin module, non-TIMP type | SFRP2, cysteine-rich domain | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R238 | InterPro | 294 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-62K15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-30K22 | ZFIN Curated Data | |
| Encodes | EST | eu233 | Thisse et al., 2005 | |
| Encodes | EST | zeh0225 | ||
| Encodes | cDNA | MGC:153618 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191125 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077384 (1) | 3161 nt | ||
| Genomic | GenBank:AL935184 (1) | 255909 nt | ||
| Polypeptide | UniProtKB:F1R238 (1) | 294 aa |
- Peng, X., Lai, K.S., She, P., Kang, J., Wang, T., Li, G., Zhou, Y., Sun, J., Jin, D., Xu, X., Liao, L., Liu, J., Lee, E., Poss, K.D., Zhong, T.P. (2020) Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Journal of molecular cell biology. 13(1):41-58
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275
- Zhu, Q., Guo, W., Zhang, S., Feng, Y., Wang, X., Greenspan, D.S., Zhou, L., Huang, G.R. (2018) Synergistic effect of PCPE1 and sFRP2 on the processing of procollagens via BMP1. FEBS letters. 593(1):119-127
- Ahmed, M.U., Maurya, A.K., Cheng, L., Jorge, E.C., Schubert, F.R., Maire, P., Basson, M.A., Ingham, P.W., Dietrich, S. (2017) Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility. Developmental Biology. 430(1):90-104
- Askary, A., Xu, P., Barske, L., Bay, M., Bump, P., Balczerski, B., Bonaguidi, M.A., Crump, J.G. (2017) Genome-wide analysis of facial skeletal regionalization in zebrafish. Development (Cambridge, England). 144(16):2994-3005
- Garcia, G.R., Goodale, B.C., Wiley, M.W., La Du, J.K., Hendrix, D.A., Tanguay, R.L. (2017) In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression.. Molecular pharmacology. 91(6):609-619
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Sasagawa, S., Nishimura, Y., Sawada, H., Zhang, E., Okabe, S., Murakami, S., Ashikawa, Y., Yuge, M., Kawaguchi, K., Kawase, R., Mitani, Y., Maruyama, K., Tanaka, T. (2016) Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension. Frontiers in pharmacology. 7:142
- Zhou, X., Yue, G.G., Liu, M., Zuo, Z., Lee, J.K., Li, M., Tsui, S.K., Fung, K.P., Sun, H., Pu, J., Lau, C.B. (2016) Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling. Oncotarget. 7(50):82820-82835
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