Gene
galnt11
- ID
- ZDB-GENE-060929-998
- Name
- UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
- Symbol
- galnt11 Nomenclature History
- Previous Names
-
- sb:cb921
- wu:fc01a10
- zgc:153274
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within determination of left/right symmetry. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in otic vesicle; pronephric duct; and solid lens vesicle. Orthologous to several human genes including GALNT11 (polypeptide N-acetylgalactosaminyltransferase 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb921 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Liu et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa16956 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-galnt11 | N/A | Gorski et al., 2015 |
MO2-galnt11 | N/A | Liu et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Glycosyltransferase 2-like | N-acetylgalactosaminyltransferase | Nucleotide-diphospho-sugar transferases | Ricin B, lectin domain | Ricin B-like lectins |
---|---|---|---|---|---|---|---|
UniProtKB:Q08CC3 | InterPro | 590 | |||||
UniProtKB:F1R7M5 | InterPro | 590 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
galnt11-201
(1)
|
Ensembl | 2,396 nt | ||
mRNA |
galnt11-205
(1)
|
Ensembl | 5,879 nt | ||
ncRNA |
galnt11-002
(1)
|
Ensembl | 453 nt | ||
ncRNA |
galnt11-003
(1)
|
Ensembl | 638 nt | ||
ncRNA |
galnt11-004
(1)
|
Ensembl | 446 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-232L14 | ||
Contains | STS | chunp30565 | ||
Encodes | EST | cb921 | Thisse et al., 2001 | |
Encodes | EST | fc01a10 | ||
Encodes | cDNA | MGC:153274 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001076562 (1) | 2405 nt | ||
Genomic | GenBank:BX294185 (1) | 115427 nt | ||
Polypeptide | UniProtKB:F1R7M5 (1) | 590 aa |
- Liu, S., Wei, W., Wang, P., Liu, C., Jiang, X., Li, T., Li, F., Wu, Y., Chen, S., Sun, K., Xu, R. (2022) LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. PLoS Genetics. 18:e1010530e1010530
- Liu, C., Cao, R., Xu, Y., Li, T., Li, F., Chen, S., Xu, R., Sun, K. (2018) Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects. Genome Medicine. 10:40
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gorski, M., Tin, A., Garnaas, M., McMahon, G.M., Chu, A.Y., Tayo, B.O., Pattaro, C., Teumer, A., Chasman, D.I., Chalmers, J., Hamet, P., Tremblay, J., Woodward, M., Aspelund, T., Eiriksdottir, G., Gudnason, V., Harris, T.B., Launer, L.J., Smith, A.V., Mitchell, B.D., O'Connell, J.R., Shuldiner, A.R., Coresh, J., Li, M., Freudenberger, P., Hofer, E., Schmidt, H., Schmidt, R., Holliday, E.G., Mitchell, P., Wang, J.J., de Boer, I.H., Li, G., Siscovick, D.S., Kutalik, Z., Corre, T., Vollenweider, P., Waeber, G., Gupta, J., Kanetsky, P.A., Hwang, S.J., Olden, M., Yang, Q., de Andrade, M., Atkinson, E.J., Kardia, S.L., Turner, S.T., Stafford, J.M., Ding, J., Liu, Y., Barlassina, C., Cusi, D., Salvi, E., Staessen, J.A., Ridker, P.M., Grallert, H., Meisinger, C., Müller-Nurasyid, M., Krämer, B.K., Kramer, H., Rosas, S.E., Nolte, I.M., Penninx, B.W., Snieder, H., Fabiola Del Greco, M., Franke, A., Nöthlings, U., Lieb, W., Bakker, S.J., Gansevoort, R.T., van der Harst, P., Dehghan, A., Franco, O.H., Hofman, A., Rivadeneira, F., Sedaghat, S., Uitterlinden, A.G., Coassin, S., Haun, M., Kollerits, B., Kronenberg, F., Paulweber, B., Aumann, N., Endlich, K., Pietzner, M., Völker, U., Rettig, R., Chouraki, V., Helmer, C., Lambert, J.C., Metzger, M., Stengel, B., Lehtimäki, T., Lyytikäinen, L.P., Raitakari, O., Johnson, A., Parsa, A., Bochud, M., Heid, I.M., Goessling, W., Köttgen, A., Kao, W.H., Fox, C.S., Böger, C.A. (2015) Genome-wide association study of kidney function decline in individuals of European descent. Kidney International. 87(5):1017-29
- Sun, X.J., Xu, P.F., Zhou, T., Hu, M., Fu, C.T., Zhang, Y., Jin, Y., Chen, Y., Chen, S.J., Huang, Q.H., Liu, T.X., and Chen, Z. (2008) Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. PLoS One. 3(1):e1499
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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